Technology Process of 3-Iodocinnoline
There total 4 articles about 3-Iodocinnoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Cinnoline;
With
boron trifluoride diethyl etherate;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
Inert atmosphere;
With
bis(2,2,6,6-tetramethylpiperidin-1-yl)magnesium-bis(lithium chloride) complex;
In
tetrahydrofuran;
at -78 ℃;
for 0.0833333h;
Inert atmosphere;
With
iodine;
In
tetrahydrofuran;
at -78 - 25 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ol5001999
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / iodine monochloride, NaOAc / acetic acid / 100 °C
2: 84 percent / POCl3 / 0.17 h / 140 °C
3: 72 percent / toluene-p-sulphonylhydrazine / CHCl3 / RT, 1 week, then reflux 1.5 h
With
sodium acetate; Iodine monochloride; toluene-4-sulfonic acid hydrazide; trichlorophosphate;
In
chloroform; acetic acid;
DOI:10.1016/0040-4020(82)80178-6
