(1-Propyl-1H-indol-3-yl)(4-propyl-naphthalen-1-yl)Methanone

Base Information

• Chemical Name: (1-Propyl-1H-indol-3-yl)(4-propyl-naphthalen-1-yl)Methanone
• CAS No.: 824959-87-7
• Molecular Formula: C₂₅H₂₅NO
• Molecular Weight: 355.48
• Mol file: 824959-87-7.mol

Synonyms:JWH-180;

Chemical Property of (1-Propyl-1H-indol-3-yl)(4-propyl-naphthalen-1-yl)Methanone

Chemical Property:

• PSA: 22.00000
• LogP: 6.38800

Purity/Quality:

99% ^*data from raw suppliers

JWH-180 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: JWH-180 is a highly selective and potent synthetic CB1 and CB2 cannabinoid receptor agonist. JWH-180 has been detected in herbal blends sold as recreational drugs

Technology Process of (1-Propyl-1H-indol-3-yl)(4-propyl-naphthalen-1-yl)Methanone

There total 4 articles about (1-Propyl-1H-indol-3-yl)(4-propyl-naphthalen-1-yl)Methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

→ (1-propyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)methanone (824959-87-7)

Guidance literature:

Reference yield:

N,N-diphenyl-4-propyl-1-naphthalenecarboxamide → (1-propyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)methanone (824959-87-7)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating

2: thionyl chloride / 0.25 h / Heating

3: 0.098 g / EtAlCl₂ / toluene; hexane / 96 h

With potassium hydroxide; thionyl chloride; ethylaluminum dichloride; In hexane; toluene; diethylene glycol; 3: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2004.09.050

Reference yield:

4-propyl-1-naphthoic acid (107777-22-0) → (1-propyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)methanone (824959-87-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0.25 h / Heating

2: 0.098 g / EtAlCl₂ / toluene; hexane / 96 h

With thionyl chloride; ethylaluminum dichloride; In hexane; toluene; 2: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2004.09.050

upstream raw materials:

1-propyl-1H-indole

4-propyl-1-naphthoic acid

Refernces

• 1、 -. "CB2-selective cannabinoid analogues". Page 24. . Retrieved 2010/02/10.