JWH-182

Base Information

• Chemical Name: JWH-182
• CAS No.: 824960-02-3
• Molecular Formula: C₂₇H₂₉NO
• Molecular Weight: 383.533
• Mol file: 824960-02-3.mol

Synonyms:

Chemical Property of JWH-182

Chemical Property:

• PSA: 22.00000
• LogP: 7.16820

Purity/Quality:

99% ^*data from raw suppliers

JWH182 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: JWH 182 is a potent synthetic cannabinoid (CB), activating the central CB1 receptor with a Ki value of 0.65 nM and the peripheral CB2 receptor with a Ki value of 1.1 nM. Its effects in cells and animals are unknown.
• Uses: JWH 182 is a potent synthetic cannabinoid (CB), activating the central CB1 receptor with a Ki value of 0.65 nM and the peripheral CB2 receptor with a Ki value of 1.1 nM. Its effects in cells and animals are unknown.[Cayman Chemical] JWH 182, is a potent synthetic cannabinoid (CB), activating the central CB1 receptor with a Ki value of 0.65 nM and the peripheral CB2 receptor with a Ki value of 1.1 nM. Synthetic Cannabinoids

Technology Process of JWH-182

There total 4 articles about JWH-182 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

→ (1-pentyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)methanone (824960-02-3)

Guidance literature:

Reference yield:

N,N-diphenyl-4-propyl-1-naphthalenecarboxamide → (1-pentyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)methanone (824960-02-3)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / bis-(2-hydroxy-ethyl) ether / 8 h / Heating

2: thionyl chloride / 0.25 h / Heating

3: 0.099 g / EtAlCl₂ / toluene; hexane / 96 h

With potassium hydroxide; thionyl chloride; ethylaluminum dichloride; In hexane; toluene; diethylene glycol; 3: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2004.09.050

Reference yield:

4-propyl-1-naphthoic acid (107777-22-0) → (1-pentyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)methanone (824960-02-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0.25 h / Heating

2: 0.099 g / EtAlCl₂ / toluene; hexane / 96 h

With thionyl chloride; ethylaluminum dichloride; In hexane; toluene; 2: Friedel-Crafts reaction;

DOI:10.1016/j.bmc.2004.09.050

upstream raw materials:

1-pentyl-1H-indole

4-propyl-1-naphthoic acid

Refernces

• 1、 -. "CB2-selective cannabinoid analogues". Page 24. . Retrieved 2010/02/10.