2-(Chloromethyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(Chloromethyl)-1,3-dioxolane
• CAS No.: 2568-30-1
• Molecular Formula: C4H7ClO2
• Molecular Weight: 122.551
• Hs Code.: 29329990
• European Community (EC) Number: 219-908-5
• NSC Number: 319115
• UNII: QR6QTL89KS
• DSSTox Substance ID: DTXSID8038809
• Nikkaji Number: J101.106E
• Wikidata: Q72453939
• Mol file: 2568-30-1.mol

Synonyms:2-Chloromethyl-1,3-dioxolane;2-(Chloromethyl)-1,3-dioxolane;2568-30-1;1,3-Dioxolane, 2-(chloromethyl)-;Chloroacetaldehyde ethylene acetal;2-(Chloromethyl)-m-dioxane;EINECS 219-908-5;NSC 319115;NSC-319115;AI3-08042;NSC319115;2-Chloromethyldioxolane;C(Cl)C1OCCO1;QR6QTL89KS;2-chloromethyl1,3-dioxolane;1,2-Bis(pyrrolidino)-ethane;SCHEMBL2637635;2-chloromethyl- 1,3-dioxolane;DTXSID8038809;IKZOMJGRWIOEDP-UHFFFAOYSA-;Chloroacetaldehyde ethylene glycol;2-Chloromethyl-[1,3]-dioxolane;BBL011357;MFCD00043402;STL146449;2-Chloromethyl-1,3-dioxolane, 97%;AKOS000268776;AS-17570;C1321;CS-0137170;FT-0652376;EN300-22286;H10733;A817973;Q-200262

Chemical Property of 2-(Chloromethyl)-1,3-dioxolane

Chemical Property:

• Appearance/Colour: Colourless liquid
• Vapor Pressure: 3.97mmHg at 25°C
• Refractive Index: n20/D 1.449(lit.)
• Boiling Point: 155.072 °C at 760 mmHg
• Flash Point: 60 °C
• PSA: 18.46000
• Density: 1.187 g/cm³
• LogP: 0.59810
• Storage Temp.: Store below +30°C.
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.0134572
• Heavy Atom Count: 7
• Complexity: 51.7

Purity/Quality:

99% ^*data from raw suppliers

2-(Chloromethyl)-1,3-dioxolane ^*data from reagent suppliers

Safty Information:

• Safety Statements: 23-24/25

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1COC(O1)CCl
• Uses: 2-(Chloromethyl)-1,3-dioxolane can be used for controlling neonicotinoid resistant pests

Technology Process of 2-(Chloromethyl)-1,3-dioxolane

There total 7 articles about 2-(Chloromethyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.6%

2-chloroethanal (107-20-0) + ethylene glycol (107-21-1) → 2-chloromethyl-1,3-dioxolane (2568-30-1)

Guidance literature:

With sulfonic group functionalized polyacrylonitrile preoxidated nanofiber mat; In cyclohexane; at 150 ℃; for 2h; Dean-Stark;

DOI:10.1016/j.apcata.2012.07.034

Reference yield: 94.0%

chloroacetaldehyde dimethyl acetal (97-97-2) + ethylene glycol (107-21-1) → 2-chloromethyl-1,3-dioxolane (2568-30-1)

Guidance literature:

DOI:10.1021/jo990227g

Reference yield: 87.0%

→ 2-chloromethyl-1,3-dioxolane (2568-30-1)

Guidance literature:

upstream raw materials:

2-(chloromethylene)-1,3-dioxolane

2-chloroethanal

ethylene glycol

chloroacetaldehyde dimethyl acetal

Downstream raw materials:

N-(1,3-dioxolan-2-ylmethyl)-2,6-dimethylaniline

doxofylline

11H-benzo[a]carbazole

imidazo[1,2-α]pyridin-3-yl-acetic acid ethyl ester

Refernces

• 1、 Gigmes, Didier,Gil, Noémie,Guillaneuf, Yohann,Lefay, Catherine,Plummer, Christopher M.,Siri, Didier,Tardy, Antoine. "Polyesters by a Radical Pathway: Rationalization of the Cyclic Ketene Acetal Efficiency". supporting information. p. 14517 - 14526. Retrieved 2020/07/13.
• 2、 Zhong, Shaofeng,Ou, Qiongrong,Shao, Linjun. "Phosphorus promoted SO42-/TiO2 solid acid catalyst for acetalization reaction". . p. 3005 - 3008. Retrieved 2015/11/27.