5-Fluoro-2-thiopheneMethanol

Base Information

• Chemical Name: 5-Fluoro-2-thiopheneMethanol
• CAS No.: 824983-56-4
• Molecular Formula: C5H5FOS
• Molecular Weight: 132.159
• Hs Code.: 2934999090
• Mol file: 824983-56-4.mol

Synonyms:5-FLUORO-2-THIOPHENEMETHANOL;5-Fluoro-2-thiophenecarbinol;(5-fluoro-2-thienyl)methanol;(5-fluoro-thiophen-2-yl)methanol;(5-fluoro-2-thienyl)methan-1-ol;2-Thiophenemethanol,5-fluoro;(5-fluorothiophene-2-yl)methanol;

Chemical Property of 5-Fluoro-2-thiopheneMethanol

Chemical Property:

• PSA: 48.47000
• LogP: 1.37950
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99% ^*data from raw suppliers

(5-fluorothiophen-2-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-thiopheneMethanol

There total 1 articles about 5-Fluoro-2-thiopheneMethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H23FOSSi (1007388-27-3) + C21H23FOSSi (1007388-26-2) → (5-fluorothiophen-2-yl)methanol (824983-56-4) + (4-fluorothiophen-2-yl)methanol (1007388-28-4)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 16h;

Reference yield: 32.7%

(5-fluorothiophen-2-yl)methanol (824983-56-4) + 2-chloro-6-(4-methanesulfonylphenyl)pyridine → C17H14FNO3S2

Guidance literature:

(5-fluorothiophen-2-yl)methanol; 2-chloro-6-(4-methanesulfonylphenyl)pyridine; With caesium carbonate; In toluene; at 20 ℃; for 0.333333h; Inert atmosphere;

With [(2-di-tert-butylphosphino-3,6-dimethoxy-2‘,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2'-amino-1,1'-biphenyl)]palladium(II) methanesulfonate; In toluene; at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

(5-fluorothiophen-2-yl)methanol (824983-56-4) + (4-fluorothiophen-2-yl)methanol (1007388-28-4) → 5-fluorothiophene-2-carbaldehyde (29669-49-6) + 4-fluoro-2-thiophenecarboxaldehyde (32431-71-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 25 ℃;

upstream raw materials:

C₂₁H₂₃FOSSi

C₂₁H₂₃FOSSi

Downstream raw materials:

5-fluorothiophene-2-carbaldehyde

4-fluoro-2-thiophenecarboxaldehyde

Refernces