2-Chloro-4-cyanopyridine

Base Information Edit

Chemical Name:2-Chloro-4-cyanopyridine
CAS No.:33252-30-1
Molecular Formula:C6H3ClN2
Molecular Weight:138.556
Hs Code.:29333990
UNII:U2S8C7U4ER
DSSTox Substance ID:DTXSID00340938
Nikkaji Number:J1.584.180J
Wikidata:Q72518000
Mol file:33252-30-1.mol

Synonyms:2-Chloro-4-cyanopyridine;33252-30-1;2-Chloroisonicotinonitrile;2-Chloropyridine-4-carbonitrile;2-Chloro-4-pyridinecarbonitrile;2-Chloro-isonicotinonitrile;4-Pyridinecarbonitrile, 2-chloro-;4-Cyano-2-chloropyridine;Isonicotinonitrile, 2-chloro-;MFCD00174318;U2S8C7U4ER;2-chloro-4-cyano pyridine;4-cyano-2-chloropyridin;UNII-U2S8C7U4ER;2-chloro -4-cyanopyridine;2-chloro-4-cyano-pyridine;2-chloro-4-pyridinenitrile;SCHEMBL222313;2-chloro-4 pyridinecarbonitrile;2-chloropyridine -4-carbonitrile;DTXSID00340938;Pyridine, 2-chloro-, 4-cyano-;BCP22779;CS-D0766;AC-226;CL0075;STK802453;AKOS005070056;2-Chloro-4-pyridinecarbonitrile, 97%;AB04394;BCP9000101;AM20061867;C1873;FT-0611958;EN300-26966;1Y-0715;AC-907/30003049;J-400291;F2158-0490

Suppliers and Price of 2-Chloro-4-cyanopyridine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Chloro-4-cyanopyridine
5g
$ 60.00

TRC
2-Chloro-4-cyanopyridine
25g
$ 165.00

TCI Chemical
2-Chloro-4-cyanopyridine >98.0%(GC)
25g
$ 100.00

TCI Chemical
2-Chloro-4-cyanopyridine >98.0%(GC)
5g
$ 44.00

SynQuest Laboratories
2-Chloro-4-cyanopyridine
50 g
$ 39.00

SynQuest Laboratories
2-Chloro-4-cyanopyridine
10 g
$ 16.00

SynQuest Laboratories
2-Chloro-4-cyanopyridine
250 g
$ 144.00

Sigma-Aldrich
2-Chloro-4-pyridinecarbonitrile 97%
5g
$ 60.20

Sigma-Aldrich
2-Chloro-4-pyridinecarbonitrile 97%
25g
$ 87.10

Matrix Scientific
2-Chloroisonicotinonitrile 98%
25g
$ 15.00

Total 143 raw suppliers

Chemical Property of 2-Chloro-4-cyanopyridine Edit

Chemical Property:

Appearance/Colour:white or light yellow crystal
Vapor Pressure:0.307mmHg at 25°C
Melting Point:69-73 °C(lit.)
Refractive Index:1.525
Boiling Point:218.9 °C at 760 mmHg
PKA:-1.60±0.10(Predicted)
Flash Point:86.2 °C
PSA：36.68000
Density:1.33 g/cm³
LogP:1.60668
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:soluble in Methanol
XLogP3:1.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:137.9984758
Heavy Atom Count:9
Complexity:137

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-cyanopyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn,Xi
Hazard Codes:Xi,Xn
Statements: 36/37/38-20/21/22
Safety Statements: 26-36-36/37/39-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=CN=C(C=C1C#N)Cl
Uses 2-Chloro-4-cyanopyridine is an intermediate used to prepare pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). It is also used to synthesize pyridinyl-tetrazoles as scaffold to identify matrix MMP-13 inhibitors for treatment of osteoarthritis.

Technology Process of 2-Chloro-4-cyanopyridine

There total 11 articles about 2-Chloro-4-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: C₆H₃ClN₂O

: 33252-30-1
2-chloro-4-pyridinenitrile

Guidance literature:: With ammonium formate; silica gel; zinc; In methanol; at 20 ℃; for 0.166667h; chemoselective reaction;
DOI:10.1002/jhet.3069