Technology Process of 2-Hexenedioic acid, 4-methyl-,
6-[(1S,2R,3E)-2,4-dimethyl-1-(2-oxopropyl)-6-[(2S,3R,5R)-tetrahydro-3
-[(4-methoxyphenyl)methoxy]-5-methyl-5-propyl-2-furanyl]-3-hexenyl]
ester, (2E,4S)-
There total 19 articles about 2-Hexenedioic acid, 4-methyl-,
6-[(1S,2R,3E)-2,4-dimethyl-1-(2-oxopropyl)-6-[(2S,3R,5R)-tetrahydro-3
-[(4-methoxyphenyl)methoxy]-5-methyl-5-propyl-2-furanyl]-3-hexenyl]
ester, (2E,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; acetic acid;
at 65 ℃;
for 0.25h;
DOI:10.1021/ja044130+
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 94 percent / DBU; LiCl / acetonitrile / 16 h / 20 °C
2.1: 100 percent / HF*pyridine / acetonitrile / 1.5 h / 20 °C
3.1: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 2 h / -78 - 20 °C
4.1: NaClO2; NaH2PO4; 2-methylbut-2-ene / 2-methyl-propan-2-ol; H2O / 2 h
5.1: Et3N; 2,4,6-trichlorobenzoyl chloride / toluene / 1 h / 20 °C
5.2: 200 mg / DMAP / toluene / 1 h
6.1: t-BuLi / tetrahydrofuran; diethyl ether; pentane / 0.08 h / -78 °C
6.2: tetrahydrofuran; diethyl ether; pentane / 1.25 h / -78 - 20 °C
6.3: 74 percent / [PdCl2(dppf)]; K3PO4; Ph3As / various solvents / 2 h / 20 °C
7.1: LiI; pyridine / 30 h / 125 °C
8.1: 16 mg / HOAc; water / 0.25 h / 65 °C
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; water; tert.-butyl lithium; pyridine hydrogenfluoride; acetic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride; lithium iodide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol; pentane;
3.1: Swern oxidation / 5.2: Yamaguchi esterification;
DOI:10.1021/ja044130+
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 100 percent / HF*pyridine / acetonitrile / 1.5 h / 20 °C
2.1: oxalyl chloride; DMSO; Et3N / CH2Cl2 / 2 h / -78 - 20 °C
3.1: NaClO2; NaH2PO4; 2-methylbut-2-ene / 2-methyl-propan-2-ol; H2O / 2 h
4.1: Et3N; 2,4,6-trichlorobenzoyl chloride / toluene / 1 h / 20 °C
4.2: 200 mg / DMAP / toluene / 1 h
5.1: t-BuLi / tetrahydrofuran; diethyl ether; pentane / 0.08 h / -78 °C
5.2: tetrahydrofuran; diethyl ether; pentane / 1.25 h / -78 - 20 °C
5.3: 74 percent / [PdCl2(dppf)]; K3PO4; Ph3As / various solvents / 2 h / 20 °C
6.1: LiI; pyridine / 30 h / 125 °C
7.1: 16 mg / HOAc; water / 0.25 h / 65 °C
With
pyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; 2,4,6-trichlorobenzoyl chloride; water; tert.-butyl lithium; pyridine hydrogenfluoride; acetic acid; dimethyl sulfoxide; triethylamine; lithium iodide;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol; pentane;
2.1: Swern oxidation / 4.2: Yamaguchi esterification;
DOI:10.1021/ja044130+
![(E)-(S)-4-Methyl-hex-2-enedioic acid 6-[(E)-(1S,2R)-6-[(2S,3R,5R)-3-(4-methoxy-benzyloxy)-5-methyl-5-propyl-tetrahydro-furan-2-yl]-2,4-dimethyl-1-(2-methyl-[1,3]dioxolan-2-ylmethyl)-hex-3-enyl] ester](/Databaselist/images/loading.webp)
