Benzonitrile,2,3,4,5-tetrafluoro-

Base Information

• Chemical Name: Benzonitrile,2,3,4,5-tetrafluoro-
• CAS No.: 16582-93-7
• Molecular Formula: C7HF4N
• Molecular Weight: 175.085
• Hs Code.: 29269090
• Mol file: 16582-93-7.mol

Synonyms:2,3,4,5-TETRAFLUOROBENZONITRILE;4-fluro-3-methylanisole;2,3,4,5-Tetrafluorobenzonitrile,98%;2,3,4,5-TETRAFLUOROB;2H-Tetrafluorobenzonitrile

Chemical Property of Benzonitrile,2,3,4,5-tetrafluoro-

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Refractive Index: n20/D 1.456(lit.)
• Boiling Point: 164.5 °C at 760 mmHg
• Flash Point: 73.3 °C
• PSA: 23.79000
• Density: 1.46 g/cm³
• LogP: 2.11468
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2,3,4,5-Tetrafluorobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn， Xi
• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:; R36/37/38:
• Safety Statements: S26:; S37/39:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzonitrile,2,3,4,5-tetrafluoro-

There total 7 articles about Benzonitrile,2,3,4,5-tetrafluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Pentafluorobenzonitrile (773-82-0) → 2,3,5,6-tetrafluorobenzonitrile (5216-17-1) + 2,3,4,5-tetrafluorobenzonitrile (16582-93-7)

Guidance literature:

With tetrabutylammonium triphenyldifluorosilicate; HSiPh₃; In tetrahydrofuran; benzene-d6; at 20 ℃; for 8h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201708003

Reference yield: 12.0%

→ 2,3,4,5-tetrafluorobenzonitrile (16582-93-7) + 1-phenylethyl cyanide (1823-91-2)

Guidance literature:

Reference yield:

2,3,4-trichloro-5-fluorobenzonitrile → 2,3,4,5-tetrafluorobenzonitrile (16582-93-7) + 3-chloro-2,4,5-trifluorobenzonitrile

Guidance literature:

With potassium fluoride; In dimethyl sulfoxide; at 140 ℃;

DOI:10.1021/jm00400a016

upstream raw materials:

1-bromo-2,3,4,5-tetrafluorobenzene

copper(I) cyanide

2,3,4,5-tetrafluorobenzamide

1,2-dibromo-3,4,5,6-tetrafluorobenzene

Downstream raw materials:

2,3,4,5-tetrafluorobenzoic acid

2,3,5-Trifluorobenzonitrile

1,4-dicyanotrifluorobenzene

2,3,4,5-tetrafluorobenzamide

Refernces

• 1、 Lv, Hongbin,Cai, Yuan-Bo,Zhang, Jun-Long. "Copper-catalyzed hydrodefluorination of fluoroarenes by copper hydride intermediates". supporting information. p. 3203 - 3207. Retrieved 2013/04/23.
• 2、 -. "Process for production of benzonitrile and benzyl alcohol". . . Retrieved 2008/06/13.