4-(1-ADAMANTYL)-2-AMINOTHIAZOLE

Base Information

• Chemical Name: 4-(1-ADAMANTYL)-2-AMINOTHIAZOLE
• CAS No.: 19735-74-1
• Molecular Formula: C13H18 N2 S
• Molecular Weight: 234.365
• Hs Code.: 2934100090
• Mol file: 19735-74-1.mol

Synonyms:Thiazole,4-(1-adamantyl)-2-amino- (8CI); 4-(1-Adamantyl)-2-aminothiazole

Chemical Property of 4-(1-ADAMANTYL)-2-AMINOTHIAZOLE

Chemical Property:

• Vapor Pressure: 2.56E-06mmHg at 25°C
• Melting Point: 215-215.5 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 390.9°Cat760mmHg
• PKA: 5.16±0.10(Predicted)
• Flash Point: 190.2°C
• PSA: 67.15000
• Density: 1.278g/cm³
• LogP: 3.77430
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive

Purity/Quality:

98%min ^*data from raw suppliers

4-Adamantan-1-yl-thiazol-2-ylamine 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Description: 2-amino-4-(1-adamantyl)-Thiazole is a synthetic intermediate useful for pharmaceutical synthesis.

Technology Process of 4-(1-ADAMANTYL)-2-AMINOTHIAZOLE

There total 4 articles about 4-(1-ADAMANTYL)-2-AMINOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 4-[(3r,5r,7r-) adamantan-1-yl]thiazol-2-amine (19735-74-1)

Guidance literature:

In ethanol; for 2h; Inert atmosphere; Reflux;

Reference yield: 94.0%

1-adamantyl bromomethyl ketone (5122-82-7) + thiourea (17356-08-0) → 4-[(3r,5r,7r-) adamantan-1-yl]thiazol-2-amine (19735-74-1)

Guidance literature:

In isopropyl alcohol; for 0.5h;

DOI:10.1021/jm8004306

Reference yield: 63.0%

1-acetyladamantane (1660-04-4) + thiourea (17356-08-0) → 4-[(3r,5r,7r-) adamantan-1-yl]thiazol-2-amine (19735-74-1)

Guidance literature:

With iodine; at 100 ℃;

DOI:10.1039/c9ra10663d

upstream raw materials:

1-adamantyl bromomethyl ketone

thiourea

9-fluorenylmethoxycarbonyl isothiocyanate

1-acetyladamantane

Downstream raw materials:

C₂₀H₂₁F₃N₂O₂S₂

3-[4-(1-adamantyl)-1,3-thiazol-2-yl]-2-(4-bromophenyl)-1,3-thiazolidin-4-one

Refernces

• 1、 -. "SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF NUCLEASES". Page/Page column 14-15; 40; 47. . Retrieved 2019/11/12.
• 2、 Annadurai, Sivakumar,Martinez, Rogelio,Canney, Daniel J.,Eidem, Tess,Dunman, Paul M.,Abou-Gharbia, Magid. "Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA". supporting information. p. 7719 - 7725. Retrieved 2013/02/21.