2,6-diMethyl-4-hydroxybenzoic acid Methyl ester

Base Information

• Chemical Name: 2,6-diMethyl-4-hydroxybenzoic acid Methyl ester
• CAS No.: 83194-70-1
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol file: 83194-70-1.mol

Synonyms:benzoic acid,4-hydroxy-2,6-dimethyl-,methyl ester;methyl 2,6-dimethyl-4-hydroxybenzoate;Dhp 218;

Chemical Property of 2,6-diMethyl-4-hydroxybenzoic acid Methyl ester

Chemical Property:

• Vapor Pressure: 0.00166mmHg at 25°C
• Boiling Point: 285.1oC at 760 mmHg
• PKA: 8.60±0.23(Predicted)
• Flash Point: 119.4oC
• PSA: 46.53000
• Density: 1.138g/cm3
• LogP: 1.79560
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl4-hydroxy-2,6-dimethylbenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-diMethyl-4-hydroxybenzoic acid Methyl ester

There total 6 articles about 2,6-diMethyl-4-hydroxybenzoic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-benzyloxy-2,6-dimethylbenzoic acid methyl ester (306297-02-9) → methyl 4-hydroxy-2,6-dimethylbenzoate (83194-70-1)

Guidance literature:

With hydrogen; 10% palladium on activated carbon; In methanol; at 25 ℃; for 17h; under 2585.81 Torr;

Reference yield: 97.0%

methyl 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate → methyl 4-hydroxy-2,6-dimethylbenzoate (83194-70-1)

Guidance literature:

With potassium peroxymonosulfate sulfate; water; In acetone; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0037-1610538

Reference yield: 82.0%

2,6-dimethyl-4-hydroxybenzoic acid (75056-97-2) + methyl iodide (74-88-4) → methyl 4-hydroxy-2,6-dimethylbenzoate (83194-70-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

methyl 8,8-dimethoxy-1,5-dimethyl-3-oxo-2-oxabicyclo<2.2.2>oct-5-ene-6-carboxylate

4-benzyloxy-2,6-dimethylbenzoic acid methyl ester

methyl 2,6-dimethyl-4-oxo-2-cyclohexene-1-carboxylate

2,6-dimethyl-4-hydroxybenzoic acid

Downstream raw materials:

methyl 2,6-dimethyl-4-octylbenzoate

C₂₈H₂₉ClN₂O₅

2-{4-chloro-3-[(2,6-dimethyl-4-{[(2S)-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-2-yl]methoxy}benzoyl)amino]phenyl}-2-methylpropanoic acid

Refernces

• 1、 Shahzadi, Tayyaba,Saleem, Rahman S. Z.,Chotana, Ghayoor A.. "Facile Synthesis of Halogen Decorated para -/ meta -Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation". . p. 4336 - 4342. Retrieved 2018/11/23.
• 2、 Tong, Hung-Chun,Reddy, K. Rajender,Liu, Shiuh-Tzung. "Copper(II)-catalyzed aromatization followed by bromination of cyclohexenones leading to phenols and bromophenols". . p. 3256 - 3261. Retrieved 2014/06/09.