2-Hydroxy-4-methoxybenzohydrazide

Base Information

• Chemical Name: 2-Hydroxy-4-methoxybenzohydrazide
• CAS No.: 41697-08-9
• Molecular Formula: C8H10 N2 O3
• Molecular Weight: 182.179
• Hs Code.: 2928000090
• European Community (EC) Number: 624-469-1
• DSSTox Substance ID: DTXSID50376969
• Wikidata: Q82165946
• Mol file: 41697-08-9.mol

Synonyms:2-hydroxy-4-methoxybenzohydrazide;41697-08-9;2-Hydroxy-4-methoxybenzenecarbohydrazide;4-methoxysalicylhydrazide;SCHEMBL4932107;DTXSID50376969;MFCD06797386;STK279064;AKOS000190165;SB85931;CS-0100349;FT-0680106;D76119;2-Hydroxy-4-methoxybenzoic acid hydrazide, 97%;EN300-3179856;12Y-0818;J-509631

Chemical Property of 2-Hydroxy-4-methoxybenzohydrazide

Chemical Property:

• Melting Point: 172-176 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 84.58000
• Density: 1.307g/cm³
• LogP: 1.09550
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 182.06914219
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxy-4-methoxybenzenecarbohydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)NN)O

Technology Process of 2-Hydroxy-4-methoxybenzohydrazide

There total 3 articles about 2-Hydroxy-4-methoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-hydroxy-4-methoxybenzoate (35031-00-6) → 2-hydroxy-4-methoxybenzohydrazide (41697-08-9)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.bmc.2010.09.051

Reference yield:

4-methoxysalicylic acid (2237-36-7) → 2-hydroxy-4-methoxybenzohydrazide (41697-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / ethanol / Reflux

With sulfuric acid; hydrazine hydrate; In ethanol;

DOI:10.1016/j.bmc.2012.03.064

Reference yield:

4-methoxymethylsalicylate (5446-02-6) → 2-hydroxy-4-methoxybenzohydrazide (41697-08-9)

Guidance literature:

With hydrazine hydrate; In ethanol; Reflux;

DOI:10.1016/j.bmc.2012.03.061

upstream raw materials:

ethyl 2-hydroxy-4-methoxybenzoate

4-methoxysalicylic acid

4-methoxymethylsalicylate

Downstream raw materials:

2-(5-mercapto-1,3,4-oxadiazol-2-yl)-5-methoxyphenol

5-methoxy-2-(5-((4-methoxybenzyl)thio)-1,3,4-oxadiazol-2-yl)phenol

5-methoxy-2-(5-((2-nitrobenzyl)thio)-1,3,4-oxadiazol-2-yl)phenol

5-methoxy-2-(5-((3-nitrobenzyl)thio)-1,3,4-oxadiazol-2-yl)phenol

Refernces

• 1、 Al-Mansury, Sadiq,Balakit, Asim A.,Alkazazz, Fatin Fadhel,Ghaleb, Rana A.. "Synthesis, Antiproliferative and Antioxidant Activity of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogues". . p. 556 - 565. Retrieved 2021/09/28.
• 2、 Du, Qian-Ru,Li, Dong-Dong,Pi, Ya-Zhou,Li, Jing-Ran,Sun, Jian,Fang, Fei,Zhong, Wei-Qing,Gong, Hai-Bin,Zhu, Hai-Liang. "Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents". . p. 2286 - 2297. Retrieved 2013/05/09.