2-(4-Methoxyphenyl)-1,3-benzoxazole

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-1,3-benzoxazole
• CAS No.: 838-34-6
• Molecular Formula: C14H11NO2
• Molecular Weight: 225.247
• DSSTox Substance ID: DTXSID10333119
• Nikkaji Number: J358.180B
• Wikidata: Q82098232
• ChEMBL ID: CHEMBL253578
• Mol file: 838-34-6.mol

Synonyms:2-(4-methoxyphenyl)-1,3-benzoxazole;838-34-6;2-(4-methoxyphenyl)benzo[d]oxazole;2-(p-methoxyphenyl)benzoxazole;2-(4-methoxyphenyl)benzoxazole;HMS1581J21;Cambridge id 5466647;Oprea1_648508;CHEMBL253578;SCHEMBL1199992;DTXSID10333119;2-(4-methoxyphenyl)-benzooxazole;1-Benzoxazol-2-yl-4-methoxybenzene;STL581866;AB00085920;4-(1,3-benzoxazol-2-yl)phenyl methyl ether;AB00085920-01;AE-641/00633004;SR-01000209694;SR-01000209694-1

Chemical Property of 2-(4-Methoxyphenyl)-1,3-benzoxazole

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 225.078978594
• Heavy Atom Count: 17
• Complexity: 251

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC3=CC=CC=C3O2

Technology Process of 2-(4-Methoxyphenyl)-1,3-benzoxazole

There total 127 articles about 2-(4-Methoxyphenyl)-1,3-benzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-methoxybenzylideneamino)phenol (117649-29-3,3117-67-7) → 2-(p-methoxyphenyl)benzoxazole (838-34-6)

Guidance literature:

With oxygen; potassium carbonate; In chloroform; water; at 30 ℃; for 20h; under 760.051 Torr;

DOI:10.1002/adsc.201100430

Reference yield: 99.0%

N-(2-iodophenyl)-4-methoxybenzamide (329939-01-7) → 2-(p-methoxyphenyl)benzoxazole (838-34-6)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; In 1,2-dimethoxyethane; for 24h; Heating;

DOI:10.1021/jo051927q

Reference yield: 99.0%

4-methoxy-benzaldehyde (123-11-5) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 2-(p-methoxyphenyl)benzoxazole (838-34-6)

Guidance literature:

With formic acid; In 1,4-dioxane; water; at 80 ℃; for 8h; Sealed tube; Green chemistry;

DOI:10.1021/jacs.7b01983

upstream raw materials:

2-(4-hydroxyphenyl)benzoxazole

dimethyl sulfate

2-(4-methoxyphenyl)quinoline-4-carboxylic acid

2-(4-methoxybenzylideneamino)phenol

Refernces

• 1、 Sudhakar, Chithaluri,Shekhar, Vanam,Shyamsunder, Manchi,Suryakumari, Adurthi,Manojkumar, Vala. "An efficient rapid synthesis of benzoxazoles and benzothiazoles using pma.Sio2 at room temperature under heterogeneous conditions". . p. 583 - 587. Retrieved 2021/09/30.
• 2、 Guo, Ying,Wang, Wei David,Li, Shengyu,Zhu, Yin,Wang, Xiaoyu,Liu, Xiao,Zhang, Yuan. "A TEMPO-Functionalized Ordered Mesoporous Polymer as a Highly Active and Reusable Organocatalyst". supporting information. p. 3689 - 3694. Retrieved 2021/09/29.