CYCLOPENTYL ISOTHIOCYANATE

Base Information

• Chemical Name: CYCLOPENTYL ISOTHIOCYANATE
• CAS No.: 33522-03-1
• Molecular Formula: C6H9NS
• Molecular Weight: 127.21
• Hs Code.: 2930909090
• Mol file: 33522-03-1.mol

Synonyms:Cyclopentylisothiocyanate;Isothiocyanatocyclopentane;

Chemical Property of CYCLOPENTYL ISOTHIOCYANATE

Chemical Property:

• Vapor Pressure: 0.352mmHg at 25°C
• Refractive Index: 1.5230
• Boiling Point: 205.8 °C at 760 mmHg
• Flash Point: 73.9 °C
• PSA: 44.45000
• Density: 1.11 g/cm³
• LogP: 2.03180
• Sensitive.: Moisture Sensitive
• Water Solubility.: Soluble in ethanol, acetone and hydrolyzes with water.

Purity/Quality:

99% ^*data from raw suppliers

Cyclopentylisothiocyanate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-36/37/38-52/53-34-25-20/21
• Safety Statements: 26-36/37/39-61-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It employed as a intermediate for pharmaceutical.

Technology Process of CYCLOPENTYL ISOTHIOCYANATE

There total 7 articles about CYCLOPENTYL ISOTHIOCYANATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

carbon disulfide (75-15-0,12122-00-8) + Cyclopentamine (1003-03-8) → cyclopentyl isothiocyanate (33522-03-1)

Guidance literature:

carbon disulfide; Cyclopentamine; With triethylamine; In ethanol; at 20 ℃;

With dmap; di-tert-butyl dicarbonate; In ethanol; at 20 ℃; for 0.25h; Further stages.;

DOI:10.1016/j.tetlet.2008.03.045

Reference yield:

thiophosgene (463-71-8) + Cyclopentamine (1003-03-8) → cyclopentyl isothiocyanate (33522-03-1)

Guidance literature:

With calcium carbonate; In dichloromethane; water; at 20 ℃; for 2h;

DOI:10.5012/bkcs.2013.34.1.271

Reference yield:

cyclopentyl thiocyanate (5263-57-0) → cyclopentyl isothiocyanate (33522-03-1)

Guidance literature:

With (isomerization); In sulfolane; at 150 ℃; Rate constant;

DOI:10.1021/jo00973a019

upstream raw materials:

cyclopentyl thiocyanate

cyclopentyl tosylate

potassium thioacyanate

carbon disulfide

Downstream raw materials:

N-cyclopentyl-N'-(toluene-4-sulfonyl)-thiourea

C₁₄H₂₀N₆S₂

N-p-Tolylsulfonyl-N'-cyclopentyl-harnstoff

1-cyclopentylthiourea

Refernces

• 1、 -. "Synthesis method of 2-aminothiazole pyrimidine serving as CDK2 inhibitor". Paragraph 0026-0027. . Retrieved 2021/03/06.
• 2、 Nam, Kee Dal,Han, Minsoo,Yoon, Jun,Kim, Eun-A,Cho, Sung-Woo,Hahn, Hoh-Gyu. "2-amino-1,3-thiazoles suppressed lipopolysaccharide-induced il-β and TNF-α". . p. 271 - 274. Retrieved 2013/08/24.