Ethyl morpholine-3-carboxylate hydrochloride

Base Information

• Chemical Name: Ethyl morpholine-3-carboxylate hydrochloride
• CAS No.: 84005-98-1
• Molecular Formula: C7H13NO3
• Molecular Weight: 195.64400
• Hs Code.: 2934999090
• Mol file: 84005-98-1.mol

Synonyms:DL-4-oxa-pipecolinic acid;(R)-MORPHOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE;3-Morpholinecarboxylicacid,(3R);3-Morpholinecarboxylicacid,(3S);ethyl morpholine-3-carboxylate;morpholine-3(S)-carboxylic acid;Morpholine-3-(R)-carboxylic acid;Morpholin-3-carbonsaeure;4-oxapipecolic acid;3-Morpholinecarboxylic acid;Ethyl3-Morpholinecarboxylate;(R)-3-MorpholinecarboxylicacidHCl;morpholine-3-carboxylic acid ethyl ester;

Chemical Property of Ethyl morpholine-3-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.00959mmHg at 25°C
• Boiling Point: 221.4±30.0 °C(Predicted)
• PKA: 7.09±0.40(Predicted)
• PSA: 47.56000
• Density: 1.078±0.06 g/cm3(Predicted)
• LogP: 0.66870
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethylmorpholine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl morpholine-3-carboxylate hydrochloride

There total 4 articles about Ethyl morpholine-3-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morpholine-3-carboxylic acid (77873-76-8,106825-81-4) + ethanol (64-17-5) → ethyl morpholine-3-carboxylate (84005-98-1,132946-21-5)

Guidance literature:

With acetyl chloride; at 0 ℃; Heating / reflux;

Reference yield: 99.0%

morpholine-3-carboxylic acid (77873-76-8,106825-81-4) + acetyl chloride (75-36-5) → ethyl morpholine-3-carboxylate (84005-98-1,132946-21-5)

Guidance literature:

In ethanol; Heating / reflux;

Reference yield:

C19H39NO3Sn → ethyl morpholine-3-carboxylate (84005-98-1,132946-21-5)

Guidance literature:

With 2,6-dimethylpyridine; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol500210z

upstream raw materials:

morpholine-3-carboxylic acid

ethanol

acetyl chloride

Refernces

• 1、 Luescher, Michael U.,Vo, Cam-Van T.,Bode, Jeffrey W.. "SnAP reagents for the synthesis of piperazines and morpholines". . p. 1236 - 1239. Retrieved 2014/03/21.
• 2、 -. "ISOTHIAZOLE DIOXIDES AS CXC- AND CC- CHEMOKINE RECEPTOR LIGANDS". Page/Page column 147-148. . Retrieved 2010/02/13.