4-Fluorophenethylamine hydrochloride

Base Information

• Chemical Name: 4-Fluorophenethylamine hydrochloride
• CAS No.: 459-19-8
• Molecular Formula: C8H10 F N . Cl H
• Molecular Weight: 175.633
• Hs Code.: 2921499090
• European Community (EC) Number: 207-285-2
• NSC Number: 93692
• DSSTox Substance ID: DTXSID30196642
• Mol file: 459-19-8.mol

Synonyms:459-19-8;4-Fluorophenethylamine hydrochloride;2-(4-fluorophenyl)ethanamine hydrochloride;2-(4-fluorophenyl)ethylamine hydrochloride;p-Fluorophenethylamine hydrochloride;EINECS 207-285-2;Phenethylamine, p-fluoro-, hydrochloride;2-(4-fluorophenyl)ethanamine;hydrochloride;MFCD00008190;2-(4-Fluorophenyl)ethan-1-amine hydrochloride;C8H10FN.ClH;SCHEMBL375725;DTXSID30196642;4-Fluoro-phenethylammonium chloride;NSC93692;NSC 93692;NSC-93692;AKOS016009769;AS-75770;SY279169;4-Fluorophenethylamine hydrochloride, 97%;2-(4-fluorophenyl)-ethylamine hydrochloride;LS-103521;F1256;FT-0632161;D97693;5-METHYL-3-PHENYL-4-ISOXAZOLYLBORONICACID;A826927

Chemical Property of 4-Fluorophenethylamine hydrochloride

Chemical Property:

• Vapor Pressure: 0.0202mmHg at 25°C
• Melting Point: 200-206 °C(lit.)
• Boiling Point: 251.7°Cat760mmHg
• Flash Point: 85.6°C
• PSA: 26.02000
• Density: 1.069g/cm³
• LogP: 2.82920
• Storage Temp.: -20°C
• Water Solubility.: Soluble in water
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 175.0564052
• Heavy Atom Count: 11
• Complexity: 87.3

Purity/Quality:

99%, ^*data from raw suppliers

4-Fluorophenethylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=CC=C1CCN)F.Cl

Technology Process of 4-Fluorophenethylamine hydrochloride

There total 6 articles about 4-Fluorophenethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-fluorophenylacetonitrile (459-22-3) → 2-(4-fluorophenyl)ethylamine hydrochloride (459-19-8)

Guidance literature:

With hydrogenchloride; hydrogen; In propan-1-ol; water; at 60 ℃; for 18h; under 375.038 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield:

4-fluoro-2-phenethylamine (1583-88-6) → 2-(4-fluorophenyl)ethylamine hydrochloride (459-19-8)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

DOI:10.1016/j.tet.2020.131439

Reference yield:

(E)-1-tert-butyl-N-(4-fluorostyryl)-1,1-dimethylsilanamine → 2-(4-fluorophenyl)ethylamine hydrochloride (459-19-8) + Bis-[2-(4-fluoro-phenyl)-ethyl]-amine; hydrochloride

Guidance literature:

(E)-1-tert-butyl-N-(4-fluorostyryl)-1,1-dimethylsilanamine; With 2.5% wt Pd/C; hydrogen; In benzene-d6; at 20 ℃; for 40h; under 760.051 Torr;

With hydrogenchloride; In diethyl ether; benzene-d6; ethyl acetate;

DOI:10.1021/jacs.7b13783

upstream raw materials:

1-(2-chloroethyl)-4-fluorobenzene

4-fluorophenylacetonitrile

4-fluoro-2-phenethylamine

Downstream raw materials:

N-(diaminomethylene)-5-(3-fluorophenyl)-1-[2-(4-fluorophenyl)ethyl]-2-methyl-1H-pyrrole-3-carboxamide

5-(3-fluorophenyl)-1-[2-(4-fluorophenyl)ethyl]-2-methyl-1H-pyrrole-3-carboxylic acid

methyl 5-(3-fluorophenyl)-1-[2-(4-fluorophenyl)ethyl]-2-methyl-1H-pyrrole-3-carboxylate

Refernces

• 1、 Ganguli, Kasturi,Mandal, Adarsha,Sarkar, Bidisha,Kundu, Sabuj. "Benzimidazole fragment containing Mn-complex catalyzed hydrosilylation of ketones and nitriles". . . Retrieved 2020/08/13.
• 2、 Saito, Yuki,Ishitani, Haruro,Ueno, Masaharu,Kobayashi, Shū. "Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO2-Supported Palladium Catalyst under Continuous-Flow Conditions". . p. 211 - 215. Retrieved 2017/04/21.