4-Aminobutanamide hydrochloride

Base Information

• Chemical Name: 4-Aminobutanamide hydrochloride
• CAS No.: 13031-62-4
• Molecular Formula: C4H11ClN2O
• Molecular Weight: 138.597
• European Community (EC) Number: 235-895-9
• UNII: CBB62LLN98
• DSSTox Substance ID: DTXSID60156451
• Mol file: 13031-62-4.mol

Synonyms:4-aminobutanamide hydrochloride;13031-62-4;4-AMINOBUTYRAMIDE HYDROCHLORIDE;4-Aminobutyramide HCl;4-aminobutanamide;hydrochloride;4-Aminobutyramide monohydrochloride;EINECS 235-895-9;Gabamide Hydrochloride;MFCD00792526;4-aminobutyric acid amide hydrochloride;Butanamide, 4-amino-, monohydrochloride;Gabaminde hydrochloride;C4H10N2O.ClH;4-AMINOBUTANAMIDE HCL;4-aminobutanamidehydrochloride;SCHEMBL856415;C4-H10-N2-O.Cl-H;DTXSID60156451;MVEPJLNIXKEKMI-UHFFFAOYSA-N;AMY15220;AKOS016008821;AS-64833;SY174709;Butanamide, 4-amino-, hydrochloride (1:1);CS-0103894;FT-0661642;EN300-39439;C72206;J-005789;Z398513418

Chemical Property of 4-Aminobutanamide hydrochloride

Chemical Property:

• Vapor Pressure: 0.0011mmHg at 25°C
• Melting Point: 126-129 °C
• Boiling Point: 300.8 °C at 760 mmHg
• Flash Point: 135.7 °C
• PSA: 69.11000
• LogP: 1.41320
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 138.0559907
• Heavy Atom Count: 8
• Complexity: 62.7

Purity/Quality:

99% ^*data from raw suppliers

4-AminobutyramideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(=O)N)CN.Cl
• Uses: Inhibitor of enzyme

Technology Process of 4-Aminobutanamide hydrochloride

There total 4 articles about 4-Aminobutanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(Benzylamino)-buttersaeureamid-Hydrochlorid (79430-84-5) → 4-aminobutyric acid amide hydrochloride (13031-62-4)

Guidance literature:

With hydrogen; palladium; In methanol; at 40 - 60 ℃; for 3h;

DOI:10.1002/ardp.19813140714

Reference yield: 73.0%

3-cyanopropionamide (61892-68-0) → 4-aminobutyric acid amide hydrochloride (13031-62-4)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In ethanol; at 30 ℃; for 3h; under 3750.3 Torr;

DOI:10.1002/jlac.198219821119

Reference yield:

ethyl γ-aminobutyrate hydrochloride (6937-16-2) → 4-aminobutyric acid amide hydrochloride (13031-62-4) + 4-amino-n-butyric acid (56-12-2)

Guidance literature:

hydrogenchloride; ammonium hydroxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) 24 h, r.t., 2.) CH₂Cl₂;

DOI:10.1016/0031-9422(88)84079-2

upstream raw materials:

3-cyanopropionamide

γ-(carbobenzoxyamino)butyramide

ethyl γ-aminobutyrate hydrochloride

4-(Benzylamino)-buttersaeureamid-Hydrochlorid

Downstream raw materials:

4-{[1-(5-Bromo-2-hydroxy-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyramide

4-{[1-(5-Chloro-2-hydroxy-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyramide

4-{[1-(2-Hydroxy-5-nitro-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyramide

4-{[1-(5-tert-Butyl-2-hydroxy-phenyl)-1-phenyl-meth-(Z)-ylidene]-amino}-butyramide

Refernces

• 1、 Smith, Terence A.,Marshall, Jacqueline H. A.. "THE OXIDATIVE DECARBOXYLATION OF ORNITHINE BY EXTRACTS OF HIGHER PLANTS". . p. 703 - 710. Retrieved 1988.
• 2、 Kleemann,Leuchtenberger,Martens,Weigel. "New pathway to 4-aminobutyramide". . p. 640 - 640. Retrieved 2007/10/02.