[(Diphenylmethyl)sulfanyl]methanimidamide hydrobromide

Base Information

• Chemical Name: [(Diphenylmethyl)sulfanyl]methanimidamide hydrobromide
• CAS No.: 90280-15-2
• Molecular Formula: C14H14N2S
• Molecular Weight: 323.256
• Hs Code.: 2930909090
• Mol file: 90280-15-2.mol

Synonyms:S-Diphenylmethyl-isothiuronium-chlorid;S-Benzhydryl-isothioharnstoff,Hydrochlorid;S-Benzhydryl-isothioharnstoff,Hydrobromid;Benzhydryl-isothioharnstoff;2-benzhydryl-isothiourea,hydrochloride;diphenylmethylisothiouronium bromide;diphenylmethylthiouronium chloride;benzhydrylthiocarboxamidine hydrochloride;benzhydrylthiocarboxamidine hydrobromide;S-benzhydryl-isothiourea,hydrochloride;S-benzhydryl-isothiourea,hydrobromide;S-Benzhydryl-isothiuronium-chlorid;S-benzhydrylthiouronium bromide;

Chemical Property of [(Diphenylmethyl)sulfanyl]methanimidamide hydrobromide

Chemical Property:

• Vapor Pressure: 6.56E-06mmHg at 25°C
• Melting Point: 180-182 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
• Boiling Point: 377.8°Cat760mmHg
• Flash Point: 182.3°C
• PSA: 75.17000
• Density: 1.15g/cm³
• LogP: 5.16080

Purity/Quality:

98%min ^*data from raw suppliers

2-BENZHYDRYL-2-THIOPSEUDOUREA HYDROBROMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(Diphenylmethyl)sulfanyl]methanimidamide hydrobromide

There total 1 articles about [(Diphenylmethyl)sulfanyl]methanimidamide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,1-Diphenylmethanol (91-01-0) + thiourea (17356-08-0) → diphenylmethylisothiouronium bromide (90280-15-2)

Guidance literature:

With hydrogen bromide; In water; at 90 ℃; for 5h;

Reference yield: 99.0%

2-(1-adamantyl)-5-(chloromethyl)-1,3-thiazole + diphenylmethylisothiouronium bromide (90280-15-2) → 5-[(benzhydrylthio)methyl]-2-(1-adamantyl)-1,3-thiazole

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 48h;

DOI:10.1021/acs.jmedchem.9b01938

Reference yield: 99.0%

4-methyl-5-thiazolylmethyl chloride (10014-52-5) + diphenylmethylisothiouronium bromide (90280-15-2) → 5-[(benzhydrylthio)methyl]-4-methylthiazole

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 48h;

DOI:10.1021/acs.jmedchem.9b01938

upstream raw materials:

1,1-Diphenylmethanol

thiourea

Downstream raw materials:

diphenylmethanethiol

methyl diphenylmethylmercaptoacetate

2-(diphenylmethylthio)acetamide

Refernces

• 1、 Saroja, Sivaprakasam R.,Aher, Yogesh D.,Kalaba, Predrag,Aher, Nilima Y.,Zehl, Martin,Korz, Volker,Subramaniyan, Saraswathi,Miklosi, Andras G.,Zanon, Lisa,Neuhaus, Winfried,H?ger, Harald,Langer, Thierry,Urban, Ernst,Leban, Johann,Lubec, Gert. "A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3". . p. 127 - 137. Retrieved 2016.
• 2、 Kalaba, Predrag,Ili?, Marija,Aher, Nilima Y.,Draga?evi?, Vladimir,Wieder, Marcus,Zehl, Martin,Wackerlig, Judith,Beyl, Stanislav,Sartori, Simone B.,Ebner, Karl,Roller, Alexander,Lukic, Natalie,Beryozkina, Tetyana,Gonzalez, Eduardo Rene Perez,Neill, Philip,Khan, Jawad Akbar,Bakulev, Vasiliy,Leban, Johann Jakob,Hering, Steffen,Pifl, Christian,Singewald, Nicolas,Lubec, Jana,Urban, Ernst,Sitte, Harald H.,Langer, Thierry,Lubec, Gert. "Structure-Activity Relationships of Novel Thiazole-Based Modafinil Analogues Acting at Monoamine Transporters". supporting information. p. 391 - 417. Retrieved 2020/02/20.