2-(BROMOMETHYL)-7-CHLOROBENZOTHIAZOLE

Base Information

• Chemical Name: 2-(BROMOMETHYL)-7-CHLOROBENZOTHIAZOLE
• CAS No.: 848696-95-7
• Molecular Formula: C8H5BrClNS
• Molecular Weight: 262.55400
• Mol file: 848696-95-7.mol

Synonyms:

Chemical Property of 2-(BROMOMETHYL)-7-CHLOROBENZOTHIAZOLE

Chemical Property:

• Boiling Point: 324.2±22.0 °C(Predicted)
• PKA: -0.88±0.30(Predicted)
• PSA: 41.13000
• Density: 1.777±0.06 g/cm3(Predicted)
• LogP: 3.84460

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(BROMOMETHYL)-7-CHLOROBENZOTHIAZOLE

There total 1 articles about 2-(BROMOMETHYL)-7-CHLOROBENZOTHIAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

7-chloro-2-methylbenzo[d]thiazole (4146-25-2) → 2-bromomethyl-7-chlorobenzothiazole (848696-95-7)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; Reflux;

DOI:10.1021/jm9016366

Reference yield: 5.0%

2,6-difluoro-3-hydroxy-benzamide (951122-37-5) + 2-bromomethyl-7-chlorobenzothiazole (848696-95-7) → 3-[(7-chloro-1,3-benzothiazol-2-yl)methoxy]-2,6-difluorobenzamide

Guidance literature:

2,6-difluoro-3-hydroxy-benzamide; With potassium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Inert atmosphere;

2-bromomethyl-7-chlorobenzothiazole; In N,N-dimethyl-formamide; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jm9016366

upstream raw materials:

7-chloro-2-methylbenzo[d]thiazole

Refernces

• 1、 -. "HIV reverse transcriptase inhibitors". Page/Page column 43. . Retrieved 2010/11/25.