2-(4-Methylphenoxy)acetohydrazide

Base Information

• Chemical Name: 2-(4-Methylphenoxy)acetohydrazide
• CAS No.: 36304-39-9
• Molecular Formula: C9H12 N2 O2
• Molecular Weight: 180.206
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID70351137
• Nikkaji Number: J656.117I
• Wikidata: Q82127309
• Mol file: 36304-39-9.mol

Synonyms:2-(4-methylphenoxy)acetohydrazide;36304-39-9;p-tolyloxy-acetic acid hydrazide;2-(p-tolyloxy)acetohydrazide;Oprea1_471046;Oprea1_551499;p-Tolyloxyacetic acid hydrazide;(4-Methylphenoxy)acetohydrazide;p-methyl-2-phenoxyacetohydrazide;SCHEMBL11872758;DTXSID70351137;p-Tolyloxy-acetic acid, hydrazide;HMS1609I02;BBL015549;MFCD00553730;STK021767;AKOS000269638;SB86413;VS-04971;CS-0204340;EN300-06175;SR-01000414393;SR-01000414393-1;F1099-0045

Chemical Property of 2-(4-Methylphenoxy)acetohydrazide

Chemical Property:

• Vapor Pressure: 1.11E-06mmHg at 25°C
• Boiling Point: 402.2°Cat760mmHg
• Flash Point: 197.1°C
• PSA: 64.35000
• Density: 1.156g/cm³
• LogP: 1.45490
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 180.089877630
• Heavy Atom Count: 13
• Complexity: 165

Purity/Quality:

98%Min ^*data from raw suppliers

2-(4-methylphenoxy)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)OCC(=O)NN

Technology Process of 2-(4-Methylphenoxy)acetohydrazide

There total 12 articles about 2-(4-Methylphenoxy)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl p-tolyloxyacetate (38768-63-7) → 4-methylphenoxyacetyl hydrazide (36304-39-9)

Guidance literature:

With hydrazine hydrate; In methanol; for 0.0166667h; microwave irradiation;

DOI:10.1081/SCC-120027275

Reference yield: 85.0%

ethyl (4-methylphenoxy)acetate (67028-40-4) → 4-methylphenoxyacetyl hydrazide (36304-39-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 5h; Reflux;

DOI:10.1007/s10895-015-1563-8

Reference yield: 84.0%

N-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-2-(p-tolyloxy)acetamide → 2-amino-1H-benzo[de]isoquinoline-1,3(2H)-dione (5690-46-0) + 4-methylphenoxyacetyl hydrazide (36304-39-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 3h; Reflux;

DOI:10.1002/chem.202102593

upstream raw materials:

ethyl (4-methylphenoxy)acetate

methyl p-tolyloxyacetate

2-(4-methylphenoxy)acetic acid

p-cresol

Downstream raw materials:

5-p-tolyloxymethyl-[1,3,4]oxadiazol-2-ylamine

3,5-dimethyl-1-(p-tolyloxy-acetyl)-1H-pyrazole

5-(p-Tolyoxyacetyl)-1-benzoyl-diaminoguanidin

4-bromo-N-(N'-p-tolyloxyacetyl-hydrazinocarbothioyl)-benzamide

Refernces

• 1、 Nguyen, Ngoc-Hong,Vo, Van-Giau,Phan, Hoang-Vinh-Truong,Ngo, Thanh-The,Sichaem, Jirapast,Nguyen, Thi-Phuong,Nguyen, Huu-Hung,Pham, Duc-Dung,Nguyen, Tien-Cong,Nguyen, Van-Kieu,Duong, Thuc-Huy. "Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents". supporting information. p. 371 - 378. Retrieved 2020/07/13.
• 2、 Gaonkar, Santosh L.,Hakkimane, Sushruta S.,Nayak, Swarnagowri,Shetty, Nitinkumar S.,Swapna, B.. "Synthesis, molecular docking and evaluation of library of 3-mercapto-1,2,4-triazole derivatives as antimicrobial agents". . p. 3039 - 3046. Retrieved 2021/12/14.