1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluoro phenyl)-

Base Information Edit

Chemical Name:1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluoro phenyl)-
CAS No.:849217-50-1
Molecular Formula:C27H21F2N3O5
Molecular Weight:505.478
Hs Code.:
Mol file:849217-50-1.mol

Synonyms:

Suppliers and Price of 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluoro phenyl)-

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluoro phenyl)- Edit

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluoro phenyl)-

There total 27 articles about 1,1-Cyclopropanedicarboxamide, N-[3-fluoro-4-[(7-hydroxy-6-methoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluoro phenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 849217-51-2
N-[3-fluoro-4-[[7-benzyloxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

: 849217-50-1
N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;

Reference yield: 55.0%

: 849217-48-7
((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

: 1372671-34-5
4-(4-amino-2-fluorophenyloxy)-6-methoxy-7-hydroxyquinoline hydrobromide

: 849217-50-1
N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 30 - 40 ℃;

Reference yield:

: 849217-48-7
((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

: 849217-50-1
N-[3-fluoro-4-[[7-hydroxy-6-methoxy-quinolin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 12 h / 15 - 20 °C

1.2: 0.5 h / 5 °C

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 5 h

With oxalyl dichloride; 5%-palladium/activated carbon; hydrogen; N,N-dimethyl-formamide; In methanol; dichloromethane;