1-(Bromomethyl)naphthalene

Base Information

• Chemical Name: 1-(Bromomethyl)naphthalene
• CAS No.: 3163-27-7
• Molecular Formula: C11H9Br
• Molecular Weight: 221.096
• Hs Code.: 29036990
• Mol file: 3163-27-7.mol

Synonyms:Naphthalene, 1-(bromomethyl)-;1-Naphthylmethyl bromide;a-(Bromomethyl)naphthalene;(1-Naphtyl)bromomethane;

Chemical Property of 1-(Bromomethyl)naphthalene

Chemical Property:

• Appearance/Colour: off-white powder
• Vapor Pressure: 0.000422mmHg at 25°C
• Melting Point: 52-55 °C
• Refractive Index: 1.663
• Boiling Point: 326 °C at 760 mmHg
• Flash Point: 151.8 °C
• PSA: 0.00000
• Density: 1.444 g/cm³
• LogP: 3.73470
• Storage Temp.: Store at 0-5°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98% ^*data from raw suppliers

1-(Bromomethyl)naphthalene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is employed as a intermediate for organic synthesis and pharmaceutical.

Technology Process of 1-(Bromomethyl)naphthalene

There total 20 articles about 1-(Bromomethyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-naphthalene methanol (4780-79-4) → 2-(bromomethyl)naphthalene (3163-27-7)

Guidance literature:

With bromocyane; triphenylphosphine; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1080/00397910903136126

Reference yield: 96.0%

1-Methylnaphthalene (90-12-0,34475-76-8) → 2-(bromomethyl)naphthalene (3163-27-7)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1246/bcsj.64.3355

Reference yield: 96.0%

1-(dimethoxymethyl)naphthalene (33250-32-7) → 2-(bromomethyl)naphthalene (3163-27-7)

Guidance literature:

With triethylsilane; Acetyl bromide; tin(II) bromide; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1246/bcsj.64.1410

upstream raw materials:

tetrachloromethane

N-Bromosuccinimide

1-Methylnaphthalene

formaldehyd

Downstream raw materials:

naphtho[2,1-b]quinolizinium bromide

2-acetyl-1-[1]naphthylmethyl-pyridinium; bromide

2-benzoyl-1-[1]naphthylmethyl-pyridinium; bromide

1-naphthaldehyde

Refernces

• 1、 Denisov, Dmitry A.,Borisov, Denis D.,Korolev, Victor A.,Novikov, Roman A.,Tomilov, Yury V.. "Three-Component GaHal3-Promoted Reactions of Substituted Methylidenemalonates and Donor-Acceptor Cyclopropanes with Propargyl Halides: Cascade Diastereoselective Construction of Five-Membered Lactones". . p. 6174 - 6182. Retrieved 2019.
• 2、 Bullpitt et al.. "-". . p. 760,762. Retrieved 1976.
• 3、 Chanda, Debabrata,Dudi, Rajesh Kumar,Fatima, Kaneez,Iqbal, Hina,Khan, Feroz,Kumar, Yogesh,Luqman, Suaib,Mondhe, D. M.,Negi, Arvind S.,Shanker, Karuna,Tabassum, Misbah,Verma, Amit Kumar. "Antiproliferative activity of diarylnaphthylpyrrolidine derivative via dual target inhibition". . . Retrieved 2020.
• 4、 -. "Preparation method of naphthalene ring C marked α .". Paragraph 0046-0047; 0050; 0056-0057; 0060; 0066-0067; 0070. . Retrieved 2021/10/05.