2H-CHROMENE-3-CARBOXYLIC ACID

Base Information

• Chemical Name: 2H-CHROMENE-3-CARBOXYLIC ACID
• CAS No.: 22649-28-1
• Molecular Formula: C10H8O3
• Molecular Weight: 176.172
• Hs Code.: 2916190090
• Mol file: 22649-28-1.mol

Synonyms:2H-Chromene-3-carboxylic acid, 90+%;

Chemical Property of 2H-CHROMENE-3-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 8.29E-05mmHg at 25°C
• Melting Point: 184-186 °C
• Boiling Point: 327.3 °C at 760 mmHg
• PKA: 3.88±0.20(Predicted)
• Flash Point: 134.8 °C
• PSA: 46.53000
• Density: 1.346 g/cm³
• LogP: 1.54700
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2H-Chromene-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-51-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-CHROMENE-3-CARBOXYLIC ACID

There total 21 articles about 2H-CHROMENE-3-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2H-chromene-3-carbaldehyde (51593-69-2) → 2H-chromene-3-carboxylic acid (22649-28-1) + (3S)-3,4-dihydro 2H-benzopyran-3-carboxylic acid

Guidance literature:

With aldehyde dehydrogenase from E_.coli; ene-reductase from Saccharomyces cerevisiae; NADH; In aq. phosphate buffer; at 30 ℃; for 1.5h; pH=7; Reagent/catalyst; stereoselective reaction; Enzymatic reaction;

DOI:10.1039/c4ob02282c

Reference yield: 5.0%

2H-chromene-3-carbaldehyde (51593-69-2) → 2H-chromene-3-carboxylic acid (22649-28-1) + 3,4-dihydro-2H-1-benzopyran-3-carboxylic acid (115822-57-6)

Guidance literature:

With aldehyde dehydrogenase from E_.coli; ene-reductase from Gluconobacter oxydans; NADH; In aq. phosphate buffer; at 30 ℃; for 5h; pH=7; Enzymatic reaction;

DOI:10.1039/c4ob02282c

Reference yield: 5.0%

2H-chromene-3-carbaldehyde (51593-69-2) → 2H-chromene-3-carboxylic acid (22649-28-1) + chromane-3-carbaldehyde (944903-95-1) + 3,4-dihydro-2H-1-benzopyran-3-carboxylic acid (115822-57-6)

Guidance literature:

With aldehyde dehydrogenase from E_.coli; ene-reductase from Saccharomyces cerevisiae; NADH; In aq. phosphate buffer; at 30 ℃; for 5h; pH=7; Enzymatic reaction;

DOI:10.1039/c4ob02282c

upstream raw materials:

ethyl?6-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

2H-chromene-3-carbaldehyde

Downstream raw materials:

chlorure d'acide chromene carboxylique-3

(2H-chromen-3-yl)methanol

3,4-dihydro-2H-1-benzopyran-3-carboxylic acid

chroman-3-one

Refernces

• 1、 -. "Substituted benzopyran analogs for the treatment of inflammation". . . Retrieved 2008/06/13.