E-CHLOROCAPRONITRILE

Base Information

• Chemical Name: E-CHLOROCAPRONITRILE
• CAS No.: 6628-78-0
• Molecular Formula: C6H10ClN
• Molecular Weight: 131.605
• Hs Code.: 2926909090
• Mol file: 6628-78-0.mol

Synonyms:6-Chlorocapronitrile;6-Chlorohexanenitrile;NSC 59713;

Chemical Property of E-CHLOROCAPRONITRILE

Chemical Property:

• Vapor Pressure: 0.0673mmHg at 25°C
• Refractive Index: 1.436
• Boiling Point: 230 °C at 760 mmHg
• Flash Point: 102.9 °C
• PSA: 23.79000
• Density: 0.994 g/cm³
• LogP: 2.30918
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

6-?Chlorohexanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-?Chlorohexanenitrile is a reagent in the synthesis of dual histamine H1 and H2 receptor antagonists. Also used in the preparation of dual action MDR anthranilamide modulators with activity against CYP450, which can assist in tumor treatment.

Technology Process of E-CHLOROCAPRONITRILE

There total 1 articles about E-CHLOROCAPRONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 6-chlorohexanenitrile (6628-78-0) + benzonitrile (100-47-0)

Guidance literature:

With phosphorus pentachloride; durch Destillation des Reaktionsproduktes;

Reference yield: 87.0%

6-chlorohexanenitrile (6628-78-0) + 8-fluoro-5-(4-fluorophenyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole (58038-68-9) → 8-fluoro-5-(4-fluorophenyl)-2-(5-cyanopentyl)-1,2,3,4-tetrahydro-γ-carboline (83535-77-7)

Guidance literature:

With sodium carbonate; potassium iodide; In various solvent(s); 1.) from 80 deg C to 90 deg C, 18 h, 2.) from 120 deg C to 130 deg C, 72 h;

DOI:10.1021/jm00151a002

Reference yield: 81.0%

1-(2,4-dihydroxy-3-propylphenyl)ethanone (40786-69-4) + 6-chlorohexanenitrile (6628-78-0) → 6-(4-acetyl-3-hydroxy-2-propylphenoxy)hexane nitrile (92518-30-4)

Guidance literature:

With potassium carbonate; potassium iodide; In butanone; for 72h; Heating;

DOI:10.1021/jm00387a018

Downstream raw materials:

6-phenoxyhexanenitrile

6-(2,4-dichloro-phenoxy)-hexanenitrile

2-amino-octanedioic acid

6-Dibenzylamino-hexanenitrile