1,2-Bis(phenylureido)ethane

Base Information

• Chemical Name: 1,2-Bis(phenylureido)ethane
• CAS No.: 849-97-8
• Molecular Formula: C16H18N4O2
• Molecular Weight: 298.345
• European Community (EC) Number: 633-062-8
• DSSTox Substance ID: DTXSID10398304
• Nikkaji Number: J814.869D
• Wikidata: Q82200191
• Mol file: 849-97-8.mol

Synonyms:1,2-BIS(PHENYLUREIDO)ETHANE;849-97-8;1-phenyl-3-[2-(phenylcarbamoylamino)ethyl]urea;ST002108;SCHEMBL11051077;DTXSID10398304;1,1'-Ethylenebis(3-phenylurea);CDTIOGUIESQOJT-UHFFFAOYSA-N;STL289966;AKOS003412936;CCG-320851;N,N'-bis(phenylcarbamoyl)-ethylenediamine;1,1'-ethane-1,2-diylbis(3-phenylurea);AE-641/00566064;N-{2-[(anilinocarbonyl)amino]ethyl}-N'-phenylurea

Chemical Property of 1,2-Bis(phenylureido)ethane

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 298.14297583
• Heavy Atom Count: 22
• Complexity: 316

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)NC(=O)NCCNC(=O)NC2=CC=CC=C2

Technology Process of 1,2-Bis(phenylureido)ethane

There total 13 articles about 1,2-Bis(phenylureido)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phenyl isocyanate (103-71-9) + ethylenediamine (107-15-3,85404-18-8) → N,N'-bis(phenylcarbamoyl)ethylenediamine (849-97-8)

Guidance literature:

In N,N-dimethyl acetamide; at 20 ℃; for 0.5h;

DOI:10.1246/bcsj.70.1185

Reference yield: 88.0%

phenyl carbamate (64-10-8) + ethylenediamine (107-15-3,85404-18-8) → N,N'-bis(phenylcarbamoyl)ethylenediamine (849-97-8)

Guidance literature:

at 110 - 120 ℃; for 6h; Ionic liquid; Green chemistry;

DOI:10.1002/hc.21244

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + N-[2-(2-oxo-3,4-diphenyl-[1,3]diazetidin-1-yl)-ethyl]-N'-phenyl-urea (854887-11-9) → N,N'-bis(phenylcarbamoyl)ethylenediamine (849-97-8) + benzaldehyde (100-52-7)

Guidance literature:

upstream raw materials:

N',N'''-dinitro-N,N''-ethanediyl-di-urea

aniline

3-benzenesulfonyloxy-dihydro-pyrimidine-2,4-dione

1,2-ethylene diisocyanate

Refernces

• 1、 -. "ORGANIC MOLECULES FOR TERAHERTZ TAGGING APPLICATIONS". Page/Page column 13. . Retrieved 2015/07/23.
• 2、 Hosseinzadeh, Rahman,Sarrafi, Yaghoub,Aghili, Nora. "An efficient and mild protocol for the synthesis of unsymmetrical ureas in the absence of catalyst and additives". experimental part. p. 1171 - 1174. Retrieved 2011/10/04.