2-Amino-3-bromo-5-nitropyridine

Base Information

• Chemical Name: 2-Amino-3-bromo-5-nitropyridine
• CAS No.: 15862-31-4
• Molecular Formula: C5H4BrN3O2
• Molecular Weight: 218.01
• Hs Code.: 29333990
• European Community (EC) Number: 689-323-1
• DSSTox Substance ID: DTXSID20370292
• Wikidata: Q72438729
• ChEMBL ID: CHEMBL1620027
• Mol file: 15862-31-4.mol

Synonyms:2-amino-3-bromo-5-nitropyridine;15862-31-4;3-bromo-5-nitropyridin-2-amine;2-Pyridinamine, 3-bromo-5-nitro-;MFCD00955628;3-bromo-5-nitro-pyridin-2-amine;3-Bromo-5-nitro-pyridin-2-ylamine;SCHEMBL914310;CHEMBL1620027;DTXSID20370292;OFXNHXMPRZDIDM-UHFFFAOYSA-N;BCP22224;STK782782;AKOS001729591;AB07738;AC-6253;CS-W002708;PS-5451;SY031463;A3497;AM20050844;FT-0637285;EN300-93430;Q-103356;Z1267727489

Chemical Property of 2-Amino-3-bromo-5-nitropyridine

Chemical Property:

• Appearance/Colour: Beige to orange-brown powder
• Vapor Pressure: 5.45E-05mmHg at 25°C
• Melting Point: 215-219 °C
• Refractive Index: 1.6200 (estimate)
• Boiling Point: 347.3 °C at 760 mmHg
• PKA: 0.06±0.49(Predicted)
• Flash Point: 163.8 °C
• PSA: 84.73000
• Density: 1.929 g/cm³
• LogP: 2.43890
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 216.94869
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-bromo-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Br)N)[N+](=O)[O-]
• Uses: 2-Amino-3-bromo-5-nitropyridine is a useful intermediate for organic synthesis.

Technology Process of 2-Amino-3-bromo-5-nitropyridine

There total 5 articles about 2-Amino-3-bromo-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9) → 3-bromo-5-nitro-pyridin-2-ylamine (15862-31-4)

Guidance literature:

5-nitro-pyridin-2-ylamine; With bromine; acetic acid; at 20 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate; pH=8 - 9; Saturated solution;

Reference yield:

2-amino-3,5-dibromopyridine (35486-42-1) → 3-bromo-5-nitro-pyridin-2-ylamine (15862-31-4)

Guidance literature:

With sulfuric acid; nitric acid;

Reference yield:

2-aminopyridine (504-29-0) → 3-bromo-5-nitro-pyridin-2-ylamine (15862-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / durch Bromierung

2: sulfuric acid; nitric acid / <0

With sulfuric acid; nitric acid;

upstream raw materials:

5-nitro-pyridin-2-ylamine

2-amino-3,5-dibromopyridine

sulfuric acid

nitric acid

Downstream raw materials:

5-nitro-3-(phenylethynyl)pyridin-2-amine

N-(5-amino-3-bromopyridin-2-yl)acetamide

3-fluoro-N-(6-oxo-5,6-dihydro-benzo[c][1,8]naphthyridin-2-yl)-benzamide

[3-bromo-5-(3-fluoro-benzoylamino)-pyridin-2-yl]-carbamic acid tert-butyl ester

Refernces

• 1、 -. "AZAINDOLE DERIVATIVES AS CFTR MODULATORS". Page/Page column 25. . Retrieved 2009/10/17.