Technology Process of Acetamide,
N-[3-[[1-[4-(2-aminoethoxy)phenyl]-2-(4-amino-1,2,5-oxadiazol-3-yl)-1H
-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]-
There total 7 articles about Acetamide,
N-[3-[[1-[4-(2-aminoethoxy)phenyl]-2-(4-amino-1,2,5-oxadiazol-3-yl)-1H
-imidazo[4,5-c]pyridin-6-yl]oxy]phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: trichlorophosphate / toluene / 16 h / 0 - 110 °C / Heating / reflux
2.1: tert.-butylhydroperoxide; potassium tert-butylate; ammonia / tetrahydrofuran; decane / 3.08 h / -78 - 0 °C
3.1: trichlorophosphate / toluene / 60 °C / Heating / reflux
4.1: triethylamine / tetrahydrofuran / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 1 h
5.2: 60 °C
6.1: hydrogen / 5%-palladium/activated carbon / methanol
7.1: 195 °C
8.1: hydrogenchloride; sodium nitrite / methanol; water / 1.17 h / 20 °C
9.1: hydroxylamine; triethylamine / 1,4-dioxane; water / 2 h / 90 °C
10.1: triethylamine / 1,4-dioxane / 3 h / 140 °C
11.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 20 °C
12.1: trifluoroacetic acid / dichloromethane / 0.5 h
With
hydrogenchloride; tert.-butylhydroperoxide; di-isopropyl azodicarboxylate; potassium tert-butylate; ammonia; hydrogen; hydroxylamine; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium nitrite; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; decane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: trichlorophosphate / toluene / 60 °C / Heating / reflux
2.1: triethylamine / tetrahydrofuran / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h
3.2: 60 °C
4.1: hydrogen / 5%-palladium/activated carbon / methanol
5.1: 195 °C
6.1: hydrogenchloride; sodium nitrite / methanol; water / 1.17 h / 20 °C
7.1: hydroxylamine; triethylamine / 1,4-dioxane; water / 2 h / 90 °C
8.1: triethylamine / 1,4-dioxane / 3 h / 140 °C
9.1: di-isopropyl azodicarboxylate; triphenylphosphine / 1,4-dioxane / 20 °C
10.1: trifluoroacetic acid / dichloromethane / 0.5 h
With
hydrogenchloride; di-isopropyl azodicarboxylate; hydrogen; hydroxylamine; sodium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium nitrite; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;