Technology Process of Acetamide,
N-[3-[[5-amino-4-[(4-hydroxyphenyl)amino]-2-pyridinyl]oxy]phenyl]-
There total 6 articles about Acetamide,
N-[3-[[5-amino-4-[(4-hydroxyphenyl)amino]-2-pyridinyl]oxy]phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
5%-palladium/activated carbon;
In
methanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: trichlorophosphate / toluene / 16 h / 0 - 110 °C / Heating / reflux
2.1: tert.-butylhydroperoxide; potassium tert-butylate; ammonia / tetrahydrofuran; decane / 3.08 h / -78 - 0 °C
3.1: trichlorophosphate / toluene / 60 °C / Heating / reflux
4.1: triethylamine / tetrahydrofuran / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 1 h
5.2: 60 °C
6.1: hydrogen / 5%-palladium/activated carbon / methanol
With
tert.-butylhydroperoxide; potassium tert-butylate; ammonia; hydrogen; sodium hydride; triethylamine; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; methanol; decane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: trichlorophosphate / toluene / 60 °C / Heating / reflux
2.1: triethylamine / tetrahydrofuran / 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1 h
3.2: 60 °C
4.1: hydrogen / 5%-palladium/activated carbon / methanol
With
hydrogen; sodium hydride; triethylamine; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;