Technology Process of Benzenesulfonamide,
3-[[2-(cyanomethyl)-1-phenyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]-N-[2-(4-
morpholinyl)ethyl]-
There total 11 articles about Benzenesulfonamide,
3-[[2-(cyanomethyl)-1-phenyl-1H-imidazo[4,5-c]pyridin-6-yl]oxy]-N-[2-(4-
morpholinyl)ethyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: trichlorophosphate / toluene / 16 h / 0 - 110 °C / Heating / reflux
2: tert.-butylhydroperoxide; potassium tert-butylate; ammonia / tetrahydrofuran; decane / 3.08 h / -78 - 0 °C
3: trichlorophosphate / toluene / 60 °C / Heating / reflux
4: triethylamine / tetrahydrofuran / 18 h / 20 °C
5: sodium hydride / N,N-dimethyl-formamide / 60 °C
6: hydrogen / 5%-palladium/activated carbon / methanol
7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C
8: acetic acid / 5 h / 110 °C
With
tert.-butylhydroperoxide; potassium tert-butylate; ammonia; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate;
5%-palladium/activated carbon;
In
tetrahydrofuran; methanol; decane; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
In
acetic acid;
at 110 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: pyridine / dichloromethane / 1.17 h / 20 °C
2: boron tribromide / dichloromethane / 2 h / -78 - 0 °C
3: sodium hydride / N,N-dimethyl-formamide / 60 °C
4: hydrogen / 5%-palladium/activated carbon / methanol
5: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C
6: acetic acid / 5 h / 110 °C
With
pyridine; hydrogen; boron tribromide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
5%-palladium/activated carbon;
In
methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;