Imidazo[2,1-b]thiazole,6-phenyl-

Base Information

• Chemical Name: Imidazo[2,1-b]thiazole,6-phenyl-
• CAS No.: 7008-63-1
• Molecular Formula: C11H8 N2 S
• Molecular Weight: 200.264
• Hs Code.: 2934100090
• Mol file: 7008-63-1.mol

Synonyms:6-Phenylimidazo[2,1-b]thiazole;NSC 266756

Chemical Property of Imidazo[2,1-b]thiazole,6-phenyl-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 45.54000
• Density: 1.29g/cm³
• LogP: 3.06280
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-phenylimidazo[2,1-b][1,3]thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Imidazo[2,1-b]thiazole,6-phenyl-

There total 29 articles about Imidazo[2,1-b]thiazole,6-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(6-phenylimidazo[2,1-b]thiazol-2-yl)methanol → 6-phenylimidazo[2,1-b]thiazole (7008-63-1)

Guidance literature:

With potassium tert-butylate; oxygen; In toluene; at 80 ℃; for 14h;

DOI:10.1021/acs.orglett.9b00563

Reference yield: 99.0%

C12H10N2OS → 6-phenylimidazo[2,1-b]thiazole (7008-63-1)

Guidance literature:

With potassium tert-butylate; oxygen; In toluene; at 80 ℃; for 14h;

DOI:10.1021/acs.orglett.9b00563

Reference yield: 86.0%

3H-thiazol-2-one (6039-97-0) + acetophenone (98-86-2) → 6-phenylimidazo[2,1-b]thiazole (7008-63-1)

Guidance literature:

With O-tosylhydroxylamine; copper(II) bis(trifluoromethanesulfonate); 1-butyl-3-methylimidazolium Tetrafluoroborate; at 110 ℃; for 0.166667h; Microwave irradiation; Green chemistry;

DOI:10.1039/c5ra09025c

upstream raw materials:

2-thiazolylamine

α-bromoacetophenone

2-(4-phenyl-1⁽³⁾H-imidazol-2-ylmercapto)-acetaldehyde-diethylacetal

ethyl 6-phenylimidazo<2,1-b>thiazole-5-carboxylate

Downstream raw materials:

5-cyanomethyl-6-phenylimidazo<2,1-b>thiazole

6-phenyl-5-(phenylthio)imidazo[2,1-b]thiazole

6-phenylimidazo[2,1-b]thiazole-5-carbonitrile

6-Phenyl-imidazo[2,1-b]thiazole-5-carbaldehyde oxime

Refernces

• 1、 Abdel-Maksoud, Mohammed S.,El-Gamal, Mohammed I.,Lee, Bong S.,Gamal El-Din, Mahmoud M.,Jeon, Hong R.,Kwon, Dow,Ammar, Usama M.,Mersal, Karim I.,Ali, Eslam M. H.,Lee, Kyung-Tae,Yoo, Kyung Ho,Han, Dong Keun,Lee, Jae Kyun,Kim, Garam,Choi, Hong Seok,Kwon, Young Jik,Lee, Kwan Hyi,Oh, Chang Hyun. "Discovery of New Imidazo[2,1- b]thiazole Derivatives as Potent Pan-RAF Inhibitors with Promising in Vitro and in Vivo Anti-melanoma Activity". . p. 6877 - 6901. Retrieved 2021/06/25.
• 2、 Yang, Zhonglie,Cao, Kun,Peng, Xiaoyan,Lin, Li,Fan, Danchen,Li, Jun-Long,Wang, Jingxia,Zhang, Xiaobin,Jiang, Hezhong,Li, Jiahong. "Micellar Catalysis: Visible-Light Mediated Imidazo[1,2-a]pyridine C—H Amination with N-Aminopyridinium Salt Accelerated by Surfactant in Water". supporting information. p. 3347 - 3352. Retrieved 2021/10/20.