N-cyclopropylthiourea

Base Information

• Chemical Name: N-cyclopropylthiourea
• CAS No.: 56541-14-1
• Molecular Formula: C4H8N2S
• Molecular Weight: 116.187
• Hs Code.: 2930909090
• European Community (EC) Number: 825-613-8
• DSSTox Substance ID: DTXSID00368935
• Wikidata: Q72461200
• Mol file: 56541-14-1.mol

Synonyms:N-cyclopropylthiourea;1-Cyclopropylthiourea;56541-14-1;cyclopropylthiourea;Thiourea, cyclopropyl-;cyclopropyl-thiourea;SCHEMBL1473973;SCHEMBL8299482;DTXSID00368935;HRRQVVNZENCVRA-UHFFFAOYSA-N;MFCD06655443;AKOS008987394;BS-28963;CS-0213021;EN300-12716;Q-101076;Z85934238

Chemical Property of N-cyclopropylthiourea

Chemical Property:

• Vapor Pressure: 0.3mmHg at 25°C
• Boiling Point: 201.9°Cat760mmHg
• PKA: 14.68±0.20(Predicted)
• Flash Point: 75.9°C
• PSA: 74.68000
• Density: 1.24g/cm³
• LogP: 1.09360
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 116.04081944
• Heavy Atom Count: 7
• Complexity: 87.7

Purity/Quality:

98%Min ^*data from raw suppliers

N-Cyclopropylthiourea ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC1NC(=S)N

Technology Process of N-cyclopropylthiourea

There total 6 articles about N-cyclopropylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclopropyl isothiocyanate (56601-42-4) → cyclopropylthiourea (56541-14-1)

Guidance literature:

With ammonia; In methanol; at 0 - 20 ℃; for 5h;

Reference yield: 90.0%

→ cyclopropylthiourea (56541-14-1)

Guidance literature:

With potassium carbonate; In ethanol; for 4h; Reflux;

Reference yield: 50.0%

→ cyclopropylthiourea (56541-14-1) + 7-methoxy-4-hydroxy-2-methoxycarbonylquinoline (77474-23-8,259214-73-8)

Guidance literature:

upstream raw materials:

N-cyclopropyl-N'-benzoylthiourea

cyclopropyl isothiocyanate

triethylammonium cyclopropyldithiocarbamate

potassium thioacyanate

Downstream raw materials:

N-(3-(5-(2-chloro-4-pyrimidinyl)-2-(cyclopropylamino)-1,3-thiazol-4-yl)phenyl)-2,6-difluorobenzamide

4-(2-bromophenyl)-N-cyclopropylthiazol-2-amine

4-[3,5-bis(methyloxy)phenyl]-5-(2-chloro-4-pyrimidinyl)-N-cyclopropyl-1,3-thiazol-2-amine

4-[4-chloro-3-(methyloxy)phenyl]-5-(2-chloro-4-pyrimidinyl)-N-cyclopropyl-1,3-thiazol-2-amine

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA". Page/Page column 73; 74. . Retrieved 2014/10/15.
• 2、 -. "NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS". Page/Page column 49-50. . Retrieved 2011/12/14.