n-Propan-2-ylglutamine

Base Information

• Chemical Name: n-Propan-2-ylglutamine
• CAS No.: 4311-12-0
• Molecular Formula: C8H16 N2 O3
• Molecular Weight: 188.227
• Hs Code.: 2924199090
• NSC Number: 23913
• DSSTox Substance ID: DTXSID60866902
• Wikidata: Q104950909
• Mol file: 4311-12-0.mol

Synonyms:n-propan-2-ylglutamine;NSC23913;Glutamine, n-isopropyl-;2-amino-5-oxo-5-(propan-2-ylamino)pentanoic acid;SCHEMBL1512837;DTXSID60866902;STR07152;NSC-23913;AKOS037655900;2-amino-4-[(propan-2-yl)carbamoyl]butanoic acid

Chemical Property of n-Propan-2-ylglutamine

Chemical Property:

• Vapor Pressure: 2.2E-08mmHg at 25°C
• Boiling Point: 424.2°Cat760mmHg
• Flash Point: 210.3°C
• PSA: 92.42000
• Density: 1.136g/cm³
• LogP: 0.79430
• Storage Temp.: Store at 0°C
• XLogP3: -3.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 188.11609238
• Heavy Atom Count: 13
• Complexity: 192

Purity/Quality:

99% ^*data from raw suppliers

H-Gln(isopropyl)-oh ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NC(=O)CCC(C(=O)O)N

Technology Process of n-Propan-2-ylglutamine

There total 6 articles about n-Propan-2-ylglutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.6%

Cbz-(L)-Glu-OBn (3705-42-8) + isopropylamine (75-31-0) → γ-L-glutamylisopropylamide (4311-12-0)

Guidance literature:

Cbz-(L)-Glu-OBn; isopropylamine; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; water; at 20 ℃; for 10h;

Reference yield:

monosodium glutamate (142-47-2) + isopropylamine (75-31-0) → γ-L-glutamylisopropylamide (4311-12-0)

Guidance literature:

With recombinant (His)6-tagged Escherichia coli K12 W3110 γ-glutamylcysteine synthetase; magnesium sulfate; ATP; In water; at 37 ℃; for 1h; pH=8.5; aq. buffer; Enzymatic reaction;

DOI:10.1271/bbb.90538

Reference yield:

N2-Benzyloxycarbonyl-N5-isopropyl-L-glutaminbenzylester (138594-81-7) → γ-L-glutamylisopropylamide (4311-12-0)

Guidance literature:

With hydrogen; palladium;

upstream raw materials:

N²-Benzyloxycarbonyl-N⁵-isopropyl-L-glutaminbenzylester

Cbz-(L)-Glu-OBn

monosodium glutamate

isopropylamine

Downstream raw materials:

L-glutamic acid

isopropylamine

Refernces

• 1、 Imaoka, Masashi,Yano, Shigekazu,Okumura, Masashi,Hibi, Takao,Wakayama, Mamoru. "Molecular cloning and characterization of γ-Glutamyltranspeptidase from pseudomonas nitroreducens IFO12694". experimental part. p. 1936 - 1939. Retrieved 2011/06/11.