Propanoic acid, 2-[4-(aminomethyl)-2-methoxyphenoxy]-2-methyl-, ethyl ester, hydrochloride

Base Information

• Chemical Name: Propanoic acid, 2-[4-(aminomethyl)-2-methoxyphenoxy]-2-methyl-, ethyl ester, hydrochloride
• CAS No.: 852814-98-3
• Molecular Formula: C14H21NO4.ClH
• Molecular Weight: 303.786
• Mol file: 852814-98-3.mol

Synonyms:

Chemical Property of Propanoic acid, 2-[4-(aminomethyl)-2-methoxyphenoxy]-2-methyl-, ethyl ester, hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of Propanoic acid, 2-[4-(aminomethyl)-2-methoxyphenoxy]-2-methyl-, ethyl ester, hydrochloride

There total 1 articles about Propanoic acid, 2-[4-(aminomethyl)-2-methoxyphenoxy]-2-methyl-, ethyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H17NO4 → ethyl 2-{[4-(aminomethyl)-2-(methyloxy)phenyl]oxy}-2-methylpropanoate hydrochloride (852814-98-3)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 42h; under 11251.1 Torr;

Reference yield: 78.0%

1-methyl-5-[4-(1-methylethyl)phenyl]-1H-pyrazole-3-carboxylic acid (852815-03-3) + ethyl 2-{[4-(aminomethyl)-2-(methyloxy)phenyl]oxy}-2-methylpropanoate hydrochloride (852814-98-3) → ethyl 2-methyl-2-{[4-{[({1-methyl-5-[4-(1-methylethyl)phenyl]-1H-pyrazol-3yl}carbonyl)amino]methyl}-2-(methyloxy)phenyl]oxy}propanoate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 24h;

Reference yield: 75.0%

5-[4-(1,1-dimethylethyl)phenyl]-1-ethyl-1H-pyrazole-3-carboxylic acid (852815-13-5) + ethyl 2-{[4-(aminomethyl)-2-(methyloxy)phenyl]oxy}-2-methylpropanoate hydrochloride (852814-98-3) → ethyl 2-{[4-{[({5-[4-(1,1-dimethylethyl)phenyl]-1-ethyl-1H-pyrazol-3-yl}carbonyl)amino]methyl}-2-(methyloxy)phenyl]oxy}-2-methylpropanoate

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 26h;

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