Technology Process of L-Phenylalaninamide,
N-[[1-[3,5-bis(1,1-dimethylethyl)phenyl]-1-methylethoxy]carbonyl]-L-phen
ylalanyl-D-leucyl-L-arginyl-
There total 7 articles about L-Phenylalaninamide,
N-[[1-[3,5-bis(1,1-dimethylethyl)phenyl]-1-methylethoxy]carbonyl]-L-phen
ylalanyl-D-leucyl-L-arginyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 57 percent / KMnO4, KOH / pyridine; H2O / 4 h / 95 °C
2: 1) SOCl2
3: 1) Mg / 1) ether, 1-2 h, heating, 2) ether, 15 h, 35 deg C
4: 71 percent / Et3N / diethyl ether / 1 h / 20 °C
5: 70 percent / NaOH / dioxane; H2O
6: 1) N-hydroxysuccinimide, DCCI, 2) 0.1 N NaOH / 1) CH3CN, 15 h, RT, 2) DMF, 20 h, RT
7: 1) N-methylmorpholine, 2) Chlorameisensaeure-isopropylester / 1) DMF, 5 min, -30 deg C, 2) DMF
With
4-methyl-morpholine; potassium hydroxide; sodium hydroxide; potassium permanganate; 1-hydroxy-pyrrolidine-2,5-dione; thionyl chloride; magnesium; isopropyl chloroformate; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; pyridine; diethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) Mg / 1) ether, 1-2 h, heating, 2) ether, 15 h, 35 deg C
2: 71 percent / Et3N / diethyl ether / 1 h / 20 °C
3: 70 percent / NaOH / dioxane; H2O
4: 1) N-hydroxysuccinimide, DCCI, 2) 0.1 N NaOH / 1) CH3CN, 15 h, RT, 2) DMF, 20 h, RT
5: 1) N-methylmorpholine, 2) Chlorameisensaeure-isopropylester / 1) DMF, 5 min, -30 deg C, 2) DMF
With
4-methyl-morpholine; sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; magnesium; isopropyl chloroformate; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; diethyl ether; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 71 percent / Et3N / diethyl ether / 1 h / 20 °C
2: 70 percent / NaOH / dioxane; H2O
3: 1) N-hydroxysuccinimide, DCCI, 2) 0.1 N NaOH / 1) CH3CN, 15 h, RT, 2) DMF, 20 h, RT
4: 1) N-methylmorpholine, 2) Chlorameisensaeure-isopropylester / 1) DMF, 5 min, -30 deg C, 2) DMF
With
4-methyl-morpholine; sodium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; isopropyl chloroformate; triethylamine; dicyclohexyl-carbodiimide;
In
1,4-dioxane; diethyl ether; water;