7-BROMO-2,4-DIAMINOQUINAZOLINE

Base Information

• Chemical Name: 7-BROMO-2,4-DIAMINOQUINAZOLINE
• CAS No.: 137553-43-6
• Molecular Formula: C8H7BrN4
• Molecular Weight: 239.074
• Hs Code.: 2933990090
• Mol file: 137553-43-6.mol

Synonyms:7-Bromoquinazoline-2,4-diamine;7-Bromo-2,4-diaminoquinazoline;

Chemical Property of 7-BROMO-2,4-DIAMINOQUINAZOLINE

Chemical Property:

• Boiling Point: 509.4 °C at 760 mmHg
• Flash Point: 261.9 °C
• PSA: 77.82000
• Density: 1.828 g/cm³
• LogP: 2.71910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

7-Bromoquinazoline-2,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-BROMO-2,4-DIAMINOQUINAZOLINE

There total 3 articles about 7-BROMO-2,4-DIAMINOQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

diguanidine carbonate (593-85-1,90332-86-8,3425-08-9) + 4-bromo-6-fluorobenzonitrile (105942-08-3) → 7-bromo-2,4-diaminoquinazoline (137553-43-6)

Guidance literature:

In N,N-dimethyl acetamide; at 150 ℃; for 6h;

Reference yield:

4-bromo-2-fluoroaniline (367-24-8) → 7-bromo-2,4-diaminoquinazoline (137553-43-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) 2N HCl, NaNO₂, 2) CuCl / 1) H₂O, 0 - 5 degC, 20 min., 2) toluene, pH 6.5 (adding Na₂CO₃), a) 0 degC, 30 min, b) r.t, 12 h

2: 59 percent / N,N-dimethyl-acetamide / 6 h / 150 °C

With hydrogenchloride; copper(l) chloride; sodium nitrite; In N,N-dimethyl acetamide;

Reference yield:

guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) + 4-bromo-6-fluorobenzonitrile (105942-08-3) → 7-bromo-2,4-diaminoquinazoline (137553-43-6)

Guidance literature:

In N,N-dimethyl-formamide; Microwave irradiation; Alkaline conditions;

DOI:10.1016/j.bmcl.2011.07.059

upstream raw materials:

diguanidine carbonate

4-bromo-6-fluorobenzonitrile

4-bromo-2-fluoroaniline

guanidine hydrogen carbonate

Downstream raw materials:

1-(3-(2,4-diaminoquinazolin-7-yl)-phenyl)ethanone

C₁₈H₂₀N₆O₄S

Refernces

• 1、 Hynes, John B.,Tomazic, Alenka,Parrish, Christie A.,Fetzer, Oliver S.. "Further Studies on the Synthesis of Quinazolines from 2-Fluorobenzonitriles". . p. 1357 - 1364. Retrieved 2007/10/02.