NIMODIPINE RELATED COMPOUND A (50 MG) (2-METHOXYETHYL 1-METHYLETHYL 2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATE)

Base Information

• Chemical Name: NIMODIPINE RELATED COMPOUND A (50 MG) (2-METHOXYETHYL 1-METHYLETHYL 2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATE)
• CAS No.: 85677-93-6
• Molecular Formula: C21H24N2O7
• Molecular Weight: 416.431
• Hs Code.: 2933399090
• Mol file: 85677-93-6.mol

Synonyms:Nimodipine Oxidized;

Chemical Property of NIMODIPINE RELATED COMPOUND A (50 MG) (2-METHOXYETHYL 1-METHYLETHYL 2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATE)

Chemical Property:

• Boiling Point: 494.5±45.0 °C(Predicted)
• PKA: 2.35±0.28(Predicted)
• PSA: 120.54000
• Density: 1?+-.0.06 g/cm3(Predicted)
• LogP: 4.16520
• Storage Temp.: Amber Vial, Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

Dehydro Nimodipine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dehydro Nimodipine is the dehydrogenated analogue and the major metabolite of the calcium channel blocker Nimodipine (N478200). Dehydro Nimodipine (Nimodipine EP Impurity A; Nimodipine USP Related Compound A) is the dehydrogenated analogue and the major metabolite of the calcium channel blocker Nimodipine (N478200).

Technology Process of NIMODIPINE RELATED COMPOUND A (50 MG) (2-METHOXYETHYL 1-METHYLETHYL 2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATE)

There total 7 articles about NIMODIPINE RELATED COMPOUND A (50 MG) (2-METHOXYETHYL 1-METHYLETHYL 2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3,5-DICARBOXYLATE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.4%

nimodipin (66085-59-4) → Nimodipine Oxidized (85677-93-6)

Guidance literature:

With potassium carbonate; eosin Y bis(tetrabutyl ammonium salt); In methanol; water; at 20 ℃; for 12h; Irradiation; Green chemistry;

DOI:10.1002/cjoc.201400521

Reference yield:

chromium(VI) oxide (1333-82-0) + nimodipin (66085-59-4) → Nimodipine Oxidized (85677-93-6)

Guidance literature:

In acetic acid;

Reference yield:

isopropyl acetoacetate (542-08-5) + 2-methoxyethyl-3-oxobutanoate (22502-03-0) + 3-nitro-benzaldehyde (99-61-6) → Nimodipine Oxidized (85677-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate / ethanol / 2 h / 80 °C

2: eosin Y bis(tetrabutyl ammonium salt); potassium carbonate / water; methanol / 12 h / 20 °C / Irradiation; Green chemistry

With ammonium acetate; potassium carbonate; eosin Y bis(tetrabutyl ammonium salt); In methanol; ethanol; water; 1: |Hantzsch Pyridine Synthesis;

DOI:10.1002/cjoc.201400521

upstream raw materials:

nimodipin

chromium(VI) oxide

isopropyl acetoacetate

2-methoxyethyl-3-oxobutanoate

Refernces

• 1、 -. "For 1, 4 - dihydro pyridine compound to prepare the corresponding pyridine compound (by machine translation)". Paragraph 0022-0024. . Retrieved 2017/08/19.
• 2、 Salazar, Ricardo,Navarrete-Encina,Squella,Barrientos,Pardo-Jiménez,Nú?ez-Vergara, Luis J.. "Study on the oxidation of C4-phenolic-1,4-dihydropyridines and its reactivity towards superoxide radical anion in dimethylsulfoxide". experimental part. p. 841 - 852. Retrieved 2011/03/22.