(2E)-3-(2,6-Difluoro-4-Methoxyphenyl)-2-propenoic Acid Ethyl Ester

Base Information

• Chemical Name: (2E)-3-(2,6-Difluoro-4-Methoxyphenyl)-2-propenoic Acid Ethyl Ester
• CAS No.: 858114-78-0
• Molecular Formula: C12H12F2O3
• Molecular Weight: 242.222
• Mol file: 858114-78-0.mol

Synonyms:(2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoic Acid Ethyl Ester;

Chemical Property of (2E)-3-(2,6-Difluoro-4-Methoxyphenyl)-2-propenoic Acid Ethyl Ester

Chemical Property:

• PSA: 35.53000
• LogP: 2.54970

Purity/Quality:

(2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2E)-3-(2,6-Difluoro-4-methoxyphenyl)-2-propenoic Acid Ethyl Ester, is an intermediate in the synthesis of 2,6-Difluoro-4-hydroxybenzenepropanoic Acid Ethyl Ester (D446215).

Technology Process of (2E)-3-(2,6-Difluoro-4-Methoxyphenyl)-2-propenoic Acid Ethyl Ester

There total 1 articles about (2E)-3-(2,6-Difluoro-4-Methoxyphenyl)-2-propenoic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

2,6-difluoro-4-methoxybenzaldehyde (256417-10-4) → ethyl (2E)-3-(2,6-difluoro-4-methoxyphenyl)acrylate (858114-78-0)

Guidance literature:

diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

2,6-difluoro-4-methoxybenzaldehyde; In tetrahydrofuran; at 0 - 35 ℃; for 4h;

Reference yield: 100.0%

ethyl (2E)-3-(2,6-difluoro-4-methoxyphenyl)acrylate (858114-78-0) → ethyl 3-(2,6-difluoro-4-methoxyphenyl)-propanoate (691905-10-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 10 - 35 ℃; for 5h;

upstream raw materials:

2,6-difluoro-4-methoxybenzaldehyde

Downstream raw materials:

ethyl 3-(2,6-difluoro-4-methoxyphenyl)-propanoate

Refernces

• 1、 -. "ALKOXYPHENYLPROPANOIC ACID DERIVATIVES". Page/Page column 33. . Retrieved 2008/06/13.