Technology Process of 4-BROMO-2-NITROPHENYLBORONIC ACID
There total 4 articles about 4-BROMO-2-NITROPHENYLBORONIC ACID which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-bromo-1-iodo-2-nitrobenzene;
With
phenylmagnesium chloride;
In
tetrahydrofuran;
at -60 ℃;
for 0.0833333h;
With
Trimethyl borate;
In
tetrahydrofuran;
at -60 ℃;
for 0.5h;
With
hydrogenchloride;
In
tetrahydrofuran;
at -20 ℃;
DOI:10.1016/j.tetlet.2005.04.129
- Guidance literature:
-
4-bromo-1-iodo-2-nitrobenzene;
With
phenylmagnesium chloride;
In
tetrahydrofuran;
at -60 ℃;
for 0.0833333h;
Inert atmosphere;
Trimethyl borate;
In
tetrahydrofuran;
for 0.5h;
Inert atmosphere;
water;
With
hydrogenchloride;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid; N-Bromosuccinimide / 1 h / Reflux
2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.5 h / 30 °C
2.2: 1 h / -10 °C
2.3: 10 h / 20 °C / Reflux; Inert atmosphere
3.1: phenylmagnesium chloride / tetrahydrofuran / 0.08 h / -60 °C / Inert atmosphere
3.2: 0.5 h / Inert atmosphere
3.3: 20 °C / Inert atmosphere
With
N-Bromosuccinimide; boron trifluoride diethyl etherate; phenylmagnesium chloride; acetic acid;
In
tetrahydrofuran;
