N-Methyl-3-nitro-aniline

Base Information

• Chemical Name: N-Methyl-3-nitro-aniline
• CAS No.: 619-26-1
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 2921430090
• Mol file: 619-26-1.mol

Synonyms:Benzenamine, N-methyl-3-nitro-;

Chemical Property of N-Methyl-3-nitro-aniline

Chemical Property:

• Vapor Pressure: 0.00534mmHg at 25°C
• Melting Point: 64-68 °C
• Refractive Index: 1.619
• Boiling Point: 274.7 °C at 760 mmHg
• PKA: 3.32±0.25(Predicted)
• Flash Point: 119.9 °C
• PSA: 57.85000
• Density: 1.26g/cm³
• LogP: 2.23270

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Methyl-3-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-Methyl-3-nitro-aniline

There total 42 articles about N-Methyl-3-nitro-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-nitro-aniline (99-09-2) + methyl iodide (74-88-4) → N-methyl-3-nitroaniline (619-26-1)

Guidance literature:

3-nitro-aniline; With trifluoroacetic anhydride; In 1,2-dichloro-ethane; at 0 ℃; for 1h;

methyl iodide; With potassium carbonate; In butanone; at 60 ℃; for 2h;

With methanol; potassium carbonate; at 20 ℃; for 1h;

DOI:10.1248/cpb.49.1420

Reference yield: 93.0%

methanol (67-56-1) + 3-nitro-aniline (99-09-2) → N-methyl-3-nitroaniline (619-26-1)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)ruthenium(III)]; bis[2-(diphenylphosphino)phenyl] ether; lithium tert-butoxide; at 100 ℃; for 24h;

DOI:10.1021/acscatal.5b00606

Reference yield: 73.0%

N,N-dimethyl-3-nitroaniline (619-31-8) → N-methyl-3-nitroaniline (619-26-1)

Guidance literature:

With air; In 1,2-dimethoxyethane; at 20 ℃; under 760.051 Torr; Irradiation;

DOI:10.1021/acs.orglett.7b01230

upstream raw materials:

methyl p-toluene sulfonate

3-nitro-aniline

N-methyl-N-nitroso-3-nitrobenzenamine

urea

Downstream raw materials:

N-methyl-N-[(4-bromophenylthio)methyl]-3-nitroaniline

N-methyl-N-(3-nitrophenyl)acrylamide

N-(m-nitrophenyl)-N-methylcyclohex-1-en-1-amine

Methyl-(3-nitro-phenyl)-thiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-yl) ester

Refernces

• 1、 Chippindale, Ann M.,Gavriel, Alexander G.,Hayes, Wayne,Khurana, Gurjeet S.,Leroux, Flavien,Lewis, Viliyana G.,Russell, Andrew T.,Sambrook, Mark R.. "Self-Immolative System for Disclosure of Reactive Electrophilic Alkylating Agents: Understanding the Role of the Reporter Group". . p. 10263 - 10279. Retrieved 2021/08/16.
• 2、 -. "SELF-IMMOLATIVE SYSTEMS". Page/Page column 22; 23. . Retrieved 2020/05/28.