2-(4-methoxyphenyl)-1H-indole

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1H-indole
• CAS No.: 5784-95-2
• Molecular Formula: C20H19ClN2O
• Molecular Weight: 223.274
• Hs Code.: 2933990090
• Mol file: 5784-95-2.mol

Synonyms:

Chemical Property of 2-(4-methoxyphenyl)-1H-indole

Chemical Property:

• Vapor Pressure: 4.88E-07mmHg at 25°C
• Melting Point: 229.0 to 233.0 °C
• Boiling Point: 425.1°Cat760mmHg
• Flash Point: 153.4°C
• PSA: 25.02000
• Density: 1.167g/cm³
• LogP: 3.84350

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(4-Methoxyphenyl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-methoxyphenyl)-1H-indole

There total 113 articles about 2-(4-methoxyphenyl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-((4-methoxyphenyl)ethynyl)aniline (157869-15-3) → 2-(4-methoxyphenyl)-1H-indole (5784-95-2)

Guidance literature:

With zinc dibromide; In toluene; at 130 ℃; for 24h;

DOI:10.1016/j.tet.2011.12.042

Reference yield: 95.0%

1-(4-methoxyphenyl)-2-(phenylamino)ethane-1-one (6037-64-5) + aniline (62-53-3) → 2-(4-methoxyphenyl)-1H-indole (5784-95-2)

Guidance literature:

1-(4-methoxyphenyl)-2-(phenylamino)ethane-1-one; aniline; With triphenylphosphine; palladium(II) bromide; In 2,2,2-trifluoroethanol; toluene; for 0.25h; Schlenk technique; Inert atmosphere;

With hydrogen; sodium sulfate; In 2,2,2-trifluoroethanol; toluene; at 150 ℃; for 24h; under 41372.9 Torr; regioselective reaction; Autoclave; Schlenk technique;

DOI:10.1002/ejoc.201900394

Reference yield: 94.0%

1-(2-nitrostyryl)-4-methoxybenzene (144535-97-7) → 2-(4-methoxyphenyl)-1H-indole (5784-95-2)

Guidance literature:

With 3,4,7,8-Tetramethyl-o-phenanthrolin; palladium diacetate; molybdenum hexacarbonyl; In N,N-dimethyl-formamide; at 100 ℃; for 10h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201500700

upstream raw materials:

2-(4'-hydroxy-phenyl)-indole

N-(4-methoxybenzylidene)-2-methylbenzenamine

2-diazo-1-(4-methoxyphenyl)ethanone

aniline

Downstream raw materials:

3-methoxy-5,6-diphenylindolo[2,1-a]isoquinoline

3-(3-cyclohexyl-1,3-diphenylpropa-1,2-dienyl)-2-(4-methoxyphenyl)-1H-indole

2-(4-methoxyphenyl)-3-((triisopropylsilyl)ethynyl)-1H-indole

N-(5,5-difluoro-3-methoxyindolo[2,1-a]isoquinolin-6(5H)-ylidene)-4-methoxyaniline

Refernces

• 1、 Liang, Hao,Zhu, Guoxun,Pu, Xiaoyun,Qiu, Liqin. "Copper-Catalyzed Enantioselective C-H Arylation between 2-Arylindoles and Hypervalent Iodine Reagents". supporting information. p. 9246 - 9250. Retrieved 2021/12/06.
• 2、 -. "Method for synthesizing 2-substituted indole derivative under catalysis of copper". Paragraph 0043-0046. . Retrieved 2021/09/11.