6-(4-FLUOROPHENYL)INDOLE

Base Information

• Chemical Name: 6-(4-FLUOROPHENYL)INDOLE
• CAS No.: 782-17-2
• Molecular Formula: C14H10FN
• Molecular Weight: 211.239
• Hs Code.: 2933990090
• Mol file: 782-17-2.mol

Synonyms:Indole,2-(p-fluorophenyl)- (7CI,8CI);2-(4-Fluorophenyl)-1H-indole;2-(4-Fluorophenyl)indole;2-p-Fluorophenylindole;

Chemical Property of 6-(4-FLUOROPHENYL)INDOLE

Chemical Property:

• Appearance/Colour: off-white to grey crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 188-191 °C(lit.)
• Refractive Index: 1.658
• Boiling Point: 389.094°C at 760 mmHg
• PKA: 16.51±0.30(Predicted)
• Flash Point: 189.118°C
• PSA: 15.79000
• Density: 1.233g/cm³
• LogP: 3.97400
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Fluorophenyl)indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37/39-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-(4-FLUOROPHENYL)INDOLE

There total 66 articles about 6-(4-FLUOROPHENYL)INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

aniline (62-53-3) + 2-bromo-4'-fluoroacetophenone (403-29-2) → 2-(4-fluorophenyl)indole (782-17-2)

Guidance literature:

With N-methylimidazolium trifluoromethanesulfonate ionic liquid supported on nano-silica; In neat (no solvent); at 110 ℃; for 0.5h; Green chemistry;

DOI:10.1007/s13738-015-0603-2

Reference yield: 95.0%

1-azido-2-((E)-4-fluorostyryl)benzene (1054567-05-3) → 2-(4-fluorophenyl)indole (782-17-2)

Guidance literature:

With rhodium(II) perfluorobutyrate dimer; In toluene; at 60 ℃; for 16h; Molecular sieve;

DOI:10.1002/anie.200800689

Reference yield: 94.0%

1-ethynyl-4-fluorobenzene (766-98-3) + 2-iodophenylamine (615-43-0) → 2-(4-fluorophenyl)indole (782-17-2)

Guidance literature:

With (diphenylphosphin)ferrocene; gold(I) iodide; potassium carbonate; In toluene; at 130 ℃; for 24h;

DOI:10.1002/ejoc.200800765

upstream raw materials:

1-(4-fluorophenyl)ethanone

phenylhydrazine

1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide

aniline

Downstream raw materials:

2-(4-Fluoro-phenyl)-3-piperidin-1-ylmethyl-1H-indole

2-(4-Fluoro-phenyl)-3-morpholin-4-ylmethyl-1H-indole

3-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-2-(4-fluoro-phenyl)-1H-indole

1-[2-(4-fluoro-phenyl)-indol-3-yl]-ethanone

Refernces

• 1、 Wan, Jin-Lin,Cui, Jian-Feng,Zhong, Wei-Qiang,Huang, Jing-Mei. "Iminyl-radicals by electrochemical decarboxylation of α-imino-oxy acids: construction of indole-fused polycyclics". supporting information. p. 10242 - 10245. Retrieved 2021/10/12.
• 2、 Vosáhlo, Petr,Radal, Leá,Labonde, Marine,Císa?ová, Ivana,Roger, Julien,Pirio, Nadine,Hierso, Jean-Cyrille,?těpni?ka, Petr. "Synthesis and Catalytic Use of Polar Phosphinoferrocene Amidosulfonates Bearing Bulky Substituents at the Ferrocene Backbone". . p. 1934 - 1944. Retrieved 2021/06/28.