5-Hydroxyuridine

Base Information

• Chemical Name: 5-Hydroxyuridine
• CAS No.: 957-77-7
• Molecular Formula: C9H12 N2 O7
• Molecular Weight: 260.203
• European Community (EC) Number: 213-487-1
• DSSTox Substance ID: DTXSID60914856
• Nikkaji Number: J236.171J
• Wikidata: Q82885692
• Mol file: 957-77-7.mol

Synonyms:5-hydroxyuridine;isobarbituridine

Chemical Property of 5-Hydroxyuridine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 145.01000
• Density: 1.848g/cm³
• LogP: -3.14630
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility.: Water (Slightly, Heated, Sonicated)
• XLogP3: -2.1
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 260.06445073
• Heavy Atom Count: 18
• Complexity: 410

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Hydroxyuridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)O
• Isomeric SMILES: C1=C(C(=O)NC(=O)N1[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O)O
• Uses: 5-Hydroxyuridine is a uridine (U829910), a nucleoside; widely distributed in nature. Uridine is one of the four basic components of ribonucleic acid (RNA).

Technology Process of 5-Hydroxyuridine

There total 3 articles about 5-Hydroxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromouridine (957-75-5) → 5',6-anhydro-6-hydroxyuridine (15425-10-2) + 1-(β-D-ribofuranosyl)-2-oxo-4-imidazoline-4-carboxylic acid (19556-57-1) + 5-Hydroxy-uridin (957-77-7) + 6-hydroxyuridine (123131-51-1)

Guidance literature:

With sodium hydroxide; at 90.1 ℃; Rate constant; Mechanism; various reagent concentration;

Reference yield:

→ 5-Hydroxy-uridin (957-77-7)

Guidance literature:

Zur Bildung aus Uridin (E III/IV 24 1202) s.;

DOI:10.1021/ja01123a026

Reference yield:

→ 5-hydroxy-uridine (957-77-7,69321-95-5)

Guidance literature:

(1), Br2, in W.;

upstream raw materials:

5-bromouridine

Downstream raw materials:

5-<(methylcarboxy)methyl>uridine

2',3'-O-isopropylidene-5-hydroxyuridine

5-(carbamoylmethyl)uridine

2',3'-O-isopropylidene-5'-O-(2-methoxy-2-propyl)-5-hydroxyuridine

Refernces

• 1、 K?ppi,L?nnberg. "Reactions of 5-bromo substituted pyrimidine nucleosides with aqueous alkalies: kinetics and mechanisms.". . p. 768 - 775. Retrieved 2007/10/02.