Indeno[4,5-b]azepine-1(2H)-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-3,4,5,8,9,10-hexahydro -7-methyl-, 1-methylethyl ester, (5S)-

Base Information

• Chemical Name: Indeno[4,5-b]azepine-1(2H)-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-3,4,5,8,9,10-hexahydro -7-methyl-, 1-methylethyl ester, (5S)-
• CAS No.: 872625-22-4
• Molecular Formula: C27H30F6N2O2
• Molecular Weight: 528.538
• Mol file: 872625-22-4.mol

Synonyms:

Chemical Property of Indeno[4,5-b]azepine-1(2H)-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-3,4,5,8,9,10-hexahydro -7-methyl-, 1-methylethyl ester, (5S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Indeno[4,5-b]azepine-1(2H)-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-3,4,5,8,9,10-hexahydro -7-methyl-, 1-methylethyl ester, (5S)-

There total 1 articles about Indeno[4,5-b]azepine-1(2H)-carboxylic acid, 5-[[[3,5-bis(trifluoromethyl)phenyl]methyl]amino]-3,4,5,8,9,10-hexahydro -7-methyl-, 1-methylethyl ester, (5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-6-(3,5-bis-trifluoromethyl-benzylamino)-4-bromo-2,3,6,7,8,9-hexahydro-1H-10-aza-cyclohepta[e]indene-10-carboxylic acid isopropyl ester (872625-21-3) + dihydroxy-methyl-borane (13061-96-6) → (S)-6-(3,5-bis-trifluoromethyl-benzylamino)-4-methyl-2,3,6,7,8,9-hexahydro-1H-10-aza-cyclohepta[e]indene-10-carboxylic acid isopropyl ester (872625-22-4)

Guidance literature:

With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 110 ℃; for 2h;

upstream raw materials:

(S)-6-(3,5-bis-trifluoromethyl-benzylamino)-4-bromo-2,3,6,7,8,9-hexahydro-1H-10-aza-cyclohepta[e]indene-10-carboxylic acid isopropyl ester

dihydroxy-methyl-borane

Refernces