Technology Process of 10-hydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene
There total 11 articles about 10-hydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
at 55 - 60 ℃;
for 3h;
DOI:10.1021/jo00171a040
- Guidance literature:
-
Multi-step reaction with 2 steps
1: HF (g)
2: 97 percent / sodium borohydride / ethanol / 3 h / 55 - 60 °C
With
sodium tetrahydroborate; hydrogen fluoride;
In
ethanol;
DOI:10.1021/jo00171a040
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi/N-isopropylcyclohexylamine / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, -78 deg C, 2 h
2: bromine, triphenyl phosphite / benzene / 1 h / Ambient temperature
3: sodium borohydride, tri-n-butyltin chloride / ethanol / 1.) room temp., 30 min, 2.) reflux, 45 min
4: KOH / ethanol / 1 h / Heating
5: HF (g)
6: 97 percent / sodium borohydride / ethanol / 3 h / 55 - 60 °C
With
triphenyl phosphite; potassium hydroxide; sodium tetrahydroborate; n-butyllithium; N-cyclohexylisopropylamine; hydrogen fluoride; tributyltin chloride; bromine;
In
ethanol; benzene;
DOI:10.1021/jo00171a040
