Pinostrobin chalcone

Base Information

• Chemical Name: Pinostrobin chalcone
• CAS No.: 18956-15-5
• Molecular Formula: C16H14 O4
• Molecular Weight: 270.285
• Hs Code.: 2914509090
• European Community (EC) Number: 278-629-7
• Nikkaji Number: J107.394J,J309.361A
• Wikidata: Q76303476
• Metabolomics Workbench ID: 26720
• ChEMBL ID: CHEMBL317221
• Mol file: 18956-15-5.mol

Synonyms:2',6'-dihydroxy-4'-methoxychalcone

Chemical Property of Pinostrobin chalcone

Chemical Property:

• Melting Point: 145°C
• Boiling Point: 521.1°Cat760mmHg
• PKA: 6.70±0.40(Predicted)
• Flash Point: 198°C
• PSA: 66.76000
• Density: 1.282g/cm³
• LogP: 3.00250
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 270.08920892
• Heavy Atom Count: 20
• Complexity: 334

Purity/Quality:

98%min ^*data from raw suppliers

PinostrobinChalcone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)O)C(=O)C=CC2=CC=CC=C2)O
• Isomeric SMILES: COC1=CC(=C(C(=C1)O)C(=O)/C=C/C2=CC=CC=C2)O
• Uses: Pinostrobin Chalcone is an estrogenic compound from the plant leaves of Carya cathayensis Sarg.

Technology Process of Pinostrobin chalcone

There total 3 articles about Pinostrobin chalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

5,7-dimethoxyflavone (1036-72-2) → pinostrobin chalcone (18956-15-5) + pinocembrin (480-39-7,61490-55-9,68745-38-0)

Guidance literature:

With N-butyl-N-methylimidazolium heptachlorodialuminate; In dichloromethane; at 40 ℃; for 4h;

DOI:10.1081/SCC-200028625

Reference yield:

pinostrobin (75291-74-6,163660-09-1) → pinostrobin chalcone (18956-15-5)

Guidance literature:

With potassium hydroxide; In methanol;

DOI:10.1016/S0960-894X(01)00617-5

Reference yield:

→ pinostrobin chalcone (18956-15-5)

Guidance literature:

upstream raw materials:

pinostrobin

5,7-dimethoxyflavone

Downstream raw materials:

2,4-dihydroxy-6-methoxyacetophenone

pinostrobin

(E)-3-phenyl-1-(2, 4, 6-trimethoxyphenyl)prop-2-en-1-one

(+/-)-(E)-1-(9'-hydroxy-5'-isopropylidene-7'-methoxy-2'-methyl-3',4'-5',6'-tetrahydro-2',6'-methano-2'H-1'-benzoxocin-10'-yl)-3-phenylprop-2-en-1-one

Refernces

• 1、 Pouget, Christelle,Lauthier, Fabienne,Simon, Alain,Fagnere, Catherine,Basly, Jean-Philippe,Delage, Christiane,Chulia, Albert-Jose. "Flavonoids: Structural requirements for antiproliferative activity on breast cancer cells". . p. 3095 - 3097. Retrieved 2007/10/03.