guanosine 2',3',5'-tribenzoate

Base Information

• Chemical Name: guanosine 2',3',5'-tribenzoate
• CAS No.: 66048-53-1
• Molecular Formula: C31H25 N5 O8
• Molecular Weight: 595.568
• Mol file: 66048-53-1.mol

Synonyms:2',3',5'-Tri-O-benzoylguanosine;

Chemical Property of guanosine 2',3',5'-tribenzoate

Chemical Property:

• Melting Point: 252-256oC
• Boiling Point: 836.7°Cat760mmHg
• Flash Point: 459.8°C
• PSA: 177.72000
• Density: 1.5g/cm³
• LogP: 3.48860

Purity/Quality:

98%Min ^*data from raw suppliers

2’,3’,5’-Tri-O-benzoylGuanosine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2’,3’,5’-Tri-O-benzoyl Guanosine (cas# 66048-53-1) is a compound useful in organic synthesis.

Technology Process of guanosine 2',3',5'-tribenzoate

There total 5 articles about guanosine 2',3',5'-tribenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

benzoyl cyanide (613-90-1) + G (118-00-3) → 2',3',5'-tri-O-benzoylguanosine (66048-53-1)

Guidance literature:

With dmap; 1-ethylene glycol monomethyl ether-3-methylimidazolium methanesulfonate; at 25 - 35 ℃;

DOI:10.1016/j.bmc.2005.04.038

Reference yield: 70.0%

benzoic acid anhydride (93-97-0) + G (118-00-3) → 2',3',5'-tri-O-benzoylguanosine (66048-53-1)

Guidance literature:

With dmap; In various solvent(s); at 50 ℃; for 4h;

DOI:10.1016/j.tetlet.2006.11.155

Reference yield:

benzoyl chloride (98-88-4) → 2',3',5'-tri-O-benzoylguanosine (66048-53-1)

Guidance literature:

With pyridine;

DOI:10.1021/ja01540a041

upstream raw materials:

benzoyl chloride

benzoyl cyanide

G

benzoic acid anhydride

Downstream raw materials:

6-thioguanosine

1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

guanosine

O^2'_,O3'_,O5'-tribenzoyl-6-thio-guanosine

Refernces

• 1、 Prasad, Ashok K.,Kumar, Vineet,Malhotra, Shashwat,Ravikumar, Vasulinga T.,Sanghvi, Yogesh S.,Parmar, Virinder S.. "'Green' methodology for efficient and selective benzoylation of nucleosides using benzoyl cyanide in an ionic liquid". . p. 4467 - 4472. Retrieved 2007/10/03.
• 2、 Vorbrueggen, Helmut,Bennua, Baerbel. "Nucleoside Syntheses, XXV. A New Simplified Nucleoside Synthesis". . p. 1279 - 1286. Retrieved 2007/10/02.