5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 51985-95-6
• Molecular Formula: C6H8N2O3
• Molecular Weight: 156.141
• Hs Code.: 2933199090
• Mol file: 51985-95-6.mol

Synonyms:Methyl5-hydroxy-1-methyl-3-pyrazolecarboxylate;NSC 338308;

Chemical Property of 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Vapor Pressure: 0.0659mmHg at 25°C
• Melting Point: 195-200°C
• Refractive Index: 1.508
• Boiling Point: 330.7 °C at 760 mmHg
• PKA: 8.26±0.28(Predicted)
• Flash Point: 153.8 °C
• PSA: 64.35000
• Density: 1.35 g/cm³
• LogP: -0.08770
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Hydroxy-1-methyl-1H-pyrazole-3-carboxylicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER

There total 7 articles about 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(1-Methylhydrazino)maleinsaeure-dimethylester (58364-79-7) → methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (51985-95-6)

Guidance literature:

2-(1-Methylhydrazino)maleinsaeure-dimethylester; With toluene-4-sulfonic acid; In xylene; for 6h; Reflux;

With sodium hydrogencarbonate; In ethyl acetate;

Reference yield: 65.0%

2-(1-Methylhydrazino)maleinsaeure-6>dimethylester (70609-03-9) → C6H5(2)H3N2O3 (70609-06-2) + methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (51985-95-6)

Guidance literature:

With Dimethyl 2-oxosuccinate; at 120 ℃; for 0.0833333h; Product distribution;

Reference yield: 12.0%

2-(1-Methylhydrazino)maleinsaeure-dimethylester (58364-79-7) → dimethyl 2-<5-hydroxy-3-(methoxycarbonyl)-1-methyl-4-pyrazolyl>fumarate (85963-51-5) + methyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (51985-95-6) + 5-hydroxy-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester (52867-42-2)

Guidance literature:

With toluene-4-sulfonic acid; In xylene; for 2h; Heating;

upstream raw materials:

2-(1-Methylhydrazino)maleinsaeure-dimethylester

2-(1-Methylhydrazino)maleinsaeure-6>dimethylester

ethyl methoxalylacetate

methylhydrazine

Refernces

• 1、 -. "SOLUBLE GUANYLATE CYCLASE ACTIVATORS". Page/Page column 69. . Retrieved 2012/09/22.
• 2、 -. "ISOXAZOLE-PYRAZOLE DERIVATIVES". Page/Page column 131. . Retrieved 2010/11/18.