Despyridyl Piroxicam (Piroxicam Impurity C)

Base Information

• Chemical Name: Despyridyl Piroxicam (Piroxicam Impurity C)
• CAS No.: 24683-25-8
• Molecular Formula: C10H10 N2 O4 S
• Molecular Weight: 254.266
• Mol file: 24683-25-8.mol

Synonyms:Despyridyl Piroxicam (Piroxicam Impurity C);4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide;2H-1,2-Benzothiazine-3-carboxamide,4-hydroxy-2-methyl-,1,1-dioxide;UNII-94RNA5J21S;Piroxicam Impurity C;

Chemical Property of Despyridyl Piroxicam (Piroxicam Impurity C)

Chemical Property:

• Vapor Pressure: 1.5E-11mmHg at 25°C
• Boiling Point: 517.9°C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 267°C
• PSA: 110.07000
• Density: 1.603g/cm³
• LogP: 2.20100

Purity/Quality:

99%+, ^*data from raw suppliers

DespyridylPiroxicam(PiroxicamImpurityC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Piroxicam impurity C; and also a metabolite of Meloxicam.

Technology Process of Despyridyl Piroxicam (Piroxicam Impurity C)

There total 4 articles about Despyridyl Piroxicam (Piroxicam Impurity C) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetate (24683-20-3) → 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide (24683-25-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOEt / ethanol

2: aq. NH₃

3: NaOMe / dimethylformamide

With ammonium hydroxide; sodium methylate; sodium ethanolate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jo00924a023

Reference yield:

4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide (24683-21-4) → 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide (24683-25-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃

2: NaOMe / dimethylformamide

With ammonium hydroxide; sodium methylate; In N,N-dimethyl-formamide;

DOI:10.1021/jo00924a023

Reference yield:

4-hydroxy-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide (24683-22-5) + methyl iodide (74-88-4) → 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide (24683-25-8)

Guidance literature:

With sodium methylate; In N,N-dimethyl-formamide;

DOI:10.1021/jo00924a023

upstream raw materials:

4-hydroxy-2H-benzo[e][1,2]thiazine-3-carboxamide 1,1-dioxide

methyl iodide

ethyl 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl) acetate

4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid ethyl ester 1,1-dioxide

Downstream raw materials:

meloxicam