3,3-diphenylpropanamide

Base Information

• Chemical Name: 3,3-diphenylpropanamide
• CAS No.: 7474-19-3
• Molecular Formula: C15H15 N O
• Molecular Weight: 225.29
• Mol file: 7474-19-3.mol

Synonyms:Propionamide, 3,3-diphenyl- (6CI,7CI); NSC 401877

Chemical Property of 3,3-diphenylpropanamide

Chemical Property:

• Vapor Pressure: 1.34E-07mmHg at 25°C
• Boiling Point: 430°Cat760mmHg
• Flash Point: 213.9°C
• PSA: 43.09000
• Density: 1.107g/cm³
• LogP: 3.39420

Purity/Quality:

99% ^*data from raw suppliers

BETA-PHENYL BENZENEPROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-diphenylpropanamide

There total 26 articles about 3,3-diphenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cinnamamide (621-79-4) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3,3-diphenylpropionamide (7474-19-3)

Guidance literature:

With aluminum (III) chloride; at 20 ℃; for 1h;

DOI:10.1039/c2ob00012a

Reference yield: 98.0%

cinnamamide (621-79-4,22031-64-7) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3,3-diphenylpropionamide (7474-19-3)

Guidance literature:

With trifluorormethanesulfonic acid; at 25 ℃; for 6h;

DOI:10.1021/ol049512z

Reference yield: 94.0%

3-phenyl-propynoic acid amide (7223-30-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 3,3-diphenylpropionamide (7474-19-3)

Guidance literature:

With aluminum (III) chloride; In cyclohexane; at 20 ℃; for 15h;

DOI:10.1016/j.tetlet.2015.09.026

upstream raw materials:

3,3-diphenyl-propionitrile

3,3-diphenylpropanoyl chloride

iodobenzene

cinnamamide

Downstream raw materials:

2-(2,2-diphenyl-ethyl)-thiazole

3,3-diphenyl-propionitrile

N-hydroxymethyl-3,3-diphenyl-propionamide

2,2-Diphenylethylamine

Refernces

• 1、 -. "Primary fatty acid amide preparation method". Paragraph 0334-0336. . Retrieved 2018/10/19.
• 2、 Nilov, Denis I.,Vasilyev, Aleksander V.. "One-pot tandem hydrophenylation and ionic hydrogenation of 3-phenylpropynoic acid derivatives under superelectrophilic activation". supporting information. p. 5714 - 5717. Retrieved 2015/09/29.