Technology Process of 2-Amino-9-[(2R,4S,5S)-4-amino-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
There total 4 articles about 2-Amino-9-[(2R,4S,5S)-4-amino-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphate buffer; cells of E.coli BMT-38; Na-acetate buffer;
at 50 ℃;
for 28h;
DOI:10.1080/15257779408013281
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) lithium azide, 2.) aq. acetic acid / 1.) DMF, 150 deg C, 3 h, 2.) 55 deg C, 4 h
2: 78 percent / Ph3P, pyridine, aq. NH3
3: 20.5 percent / cells of E.coli BMT-38, Na-acetate buffer, phosphate buffer, pH 6.75 / 28 h / 50 °C
With
pyridine; ammonium hydroxide; phosphate buffer; lithium azide; cells of E.coli BMT-38; Na-acetate buffer; acetic acid; triphenylphosphine;
DOI:10.1080/15257779408013281
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 78 percent / Ph3P, pyridine, aq. NH3
2: 20.5 percent / cells of E.coli BMT-38, Na-acetate buffer, phosphate buffer, pH 6.75 / 28 h / 50 °C
With
pyridine; ammonium hydroxide; phosphate buffer; cells of E.coli BMT-38; Na-acetate buffer; triphenylphosphine;
DOI:10.1080/15257779408013281
