3-AMINO-4-METHYL-6-PHENYLPYRIDAZINE

Base Information

• Chemical Name: 3-AMINO-4-METHYL-6-PHENYLPYRIDAZINE
• CAS No.: 81819-90-1
• Molecular Formula: C11H11N3
• Molecular Weight: 185.228
• Hs Code.: 2933990090
• Mol file: 81819-90-1.mol

Synonyms:3-Amino-4-methyl-6-phenylpyridazine;

Chemical Property of 3-AMINO-4-METHYL-6-PHENYLPYRIDAZINE

Chemical Property:

• Vapor Pressure: 2.05E-06mmHg at 25°C
• Refractive Index: 1.619
• Boiling Point: 393.9 °C at 760 mmHg
• Flash Point: 220.6 °C
• PSA: 51.80000
• Density: 1.159 g/cm³
• LogP: 2.61540

Purity/Quality:

98% ^*data from raw suppliers

4-Methyl-6-phenylpyridazin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-4-METHYL-6-PHENYLPYRIDAZINE

There total 5 articles about 3-AMINO-4-METHYL-6-PHENYLPYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C27H27N3O2 → 3-amino-4-methyl-6-phenyl-pyridazine (81819-90-1)

Guidance literature:

With trifluoroacetic acid; at 50 ℃; for 1h;

DOI:10.1021/acs.joc.1c00851

Reference yield: 76.0%

3-hydrazino-4-methyl-6-phenyl-pyridazine (32723-48-1) → 3-amino-4-methyl-6-phenyl-pyridazine (81819-90-1)

Guidance literature:

With potassium hydroxide; aluminum nickel; In methanol; for 2h; Ambient temperature;

DOI:10.1021/jo00037a059

Reference yield: 48.0%

3-chloro-4-methyl-6-phenylpyridazine (28657-39-8) → 3-amino-4-methyl-6-phenyl-pyridazine (81819-90-1)

Guidance literature:

With sodium amide; In xylene; for 48h; Heating;

upstream raw materials:

3-chloro-4-methyl-6-phenylpyridazine

3-hydrazino-4-methyl-6-phenyl-pyridazine

4-methyl-6-phenylpyridazin-3(2H)-one

Downstream raw materials:

6-Amino-1-(3-ethoxycarbonyl-1-methyl-propyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide

6-Amino-1-(4-ethoxycarbonyl-butyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide

3-imino-2-[(3-methoxy-5-isoxazolyl)-methyl] 4-methyl-6-phenyl-2,3-dihydro-pyridazine

6-Amino-1-(3-carboxy-1-methyl-propyl)-5-methyl-3-phenyl-pyridazin-1-ium; bromide

Refernces

• 1、 Sitamze,Schmitt,Wermuth. "A general and convenient synthesis of 3-aminopyridazines". . p. 3257 - 3258. Retrieved 2007/10/02.
• 2、 -. "Herbicidal pyridazines and method for controlling undesirable plant species". . . Retrieved 2008/06/13.